Analytical Data
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Gene name
PAGE2B
- Application
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Alternative Names
CT16.5; G antigen family E 3; GAGEE3; GGEE3_HUMAN; P antigen family member 2B; PAGE 2B; PAGE family member 2B; PAGE-2B; PAGE2B; Prostate associated gene 2B protein; Prostate-associated gene 2B protein; Putative G antigen family E member 3
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q5JRK9
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Expression Region
1-111 aa
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AA Sequence
MSEHVRTRSQ SSERGNDQES SQPVGSVIVQ EPTEEKRQEE EPPTDNQGIA PSGEIENEGA PAVQGPDMEA FQQELALLKI EDEPGDGPDV REGIMPTFDL TKVLEAGDAQ P
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Molecular Weight
12.0 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PAGE2B, a member of the preferentially expressed antigens in melanoma (PAGE) family, has garnered attention in cancer immunology due to its restricted expression pattern primarily in malignant tissues and testicular germ cells, making it a potential target for immunotherapy. This protein is encoded by a gene located on the X chromosome, which contributes to its unique expression profile that is absent in most normal adult tissues. Research has demonstrated that PAGE2B can elicit strong T-cell responses in melanoma patients, suggesting its immunogenic potential as a tumor-associated antigen. Additionally, the role of PAGE2B in various cancers, including non-small cell lung cancer and renal cell carcinoma, highlights its importance as a biomarker for tumor progression and patient prognosis. The study of PAGE2B is crucial for the development of personalized cancer vaccines and adoptive T-cell therapies, as it may enhance the target specificity while minimizing off-target effects on healthy tissues. Understanding the mechanisms governing PAGE2B expression and its interaction with the immune system may provide insights into novel therapeutic strategies for cancer treatment, paving the way for advancement in precision medicine. Given the increasing interest in neoantigens and the immune system's role in cancer evolution, PAGE2B represents a compelling subject for ongoing research aimed at leveraging the body's immune response to fight cancer effectively.
