Analytical Data
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基因名
P53AIP1
- Application
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别名
p53 regulated apoptosis inducing protein 1; p53-regulated apoptosis-inducing protein 1; P53AIP 1; p53AIP1; TP53AIP 1; TP53AIP1; TPIP1_HUMAN
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9HCN2
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表达区间
1-108 aa
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氨基酸序列
MGSSSEASFRSAQASCSGARRQGLGRGDQNLSVMPPNGRAQTHTPGWVSPCSENRDGLLPATAPGRLCSHRGADIPSFQTHQDPVTASGSSELHADCPQFRALDRAGN
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分子量
12.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
P53AIP1, or p53 Apoptosis Inducing Protein 1, is a crucial mediator in the p53 signaling pathway, which plays a vital role in regulating cell cycle, apoptosis, and genomic stability. The p53 protein, often referred to as the "guardian of the genome," acts as a tumor suppressor, preventing the proliferation of cells that harbor DNA damage. P53AIP1 is upregulated in response to p53 activation and is implicated in facilitating apoptosis in response to stress signals. Understanding the role of P53AIP1 in the apoptotic process has significant implications for cancer research, as it may provide insight into how cells evade apoptosis in tumor development. Moreover, the study of P53AIP1’s structure and function can unveil potential therapeutic targets for enhancing cancer treatment, as many cancers exhibit mutations in the p53 pathway, leading to decreased efficacy of standard therapies. Recent advancements in recombinant protein technology have enabled the production of P53AIP1 in a laboratory setting, allowing researchers to investigate its biochemical properties, interaction with other proteins, and functional mechanisms. By characterizing P53AIP1, scientists aim to elucidate its role in apoptosis and its potential as a biomarker for cancer prognosis, as well as a target for new therapeutic strategies. The ongoing research into P53AIP1 not only enhances our understanding of fundamental cellular processes but also opens avenues for developing novel treatments for malignancies associated with p53 dysfunction.












