Analytical Data
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基因名
P2RY4
- Application
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别名
P2RY4; NRU; P2Y purinoceptor 4; P2Y4; P2P; Uridine nucleotide receptor; UNR
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P51582
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表达区间
1-365 aa
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氨基酸序列
MASTESSLLRSLGLSPGPGSSEVELDCWFDEDFKFILLPVSYAVVFVLGLGLNAPTLWLF IFRLRPWDATATYMFHLALSDTLYVLSLPTLIYYYAAHNHWPFGTEICKFVRFLFYWNLY CSVLFLTCISVHRYLGICHPLRALRWGRPRLAGLLCLAVWLVVAGCLVPNLFFVTTSNKG TTVLCHDTTRPEEFDHYVHFSSAVMGLLFGVPCLVTLVCYGLMARRLYQPLPGSAQSSSR LRSLRTIAVVLTVFAVCFVPFHITRTIYYLARLLEADCRVLNIVNVVYKVTRPLASANSC LDPVLYLLTGDKYRRQLRQLCGGGKPQPRTAASSLALVSLPEDSSCRWAATPQDSSCSTP RADRL
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分子量
40.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
P2RY4, a member of the purinergic receptor family, encodes the adenosine receptor subtype P2Y4. This receptor is G protein-coupled and is primarily activated by extracellular nucleotides such as ATP and UTP. P2RY4 plays a vital role in various physiological processes, including cell signaling, immune responses, and inflammation regulation. Research has shown that P2RY4 is implicated in several pathophysiological conditions, including respiratory diseases and cancer, highlighting its potential as a therapeutic target. The study of P2RY4 recombinant protein is crucial for understanding its structure, function, and signaling mechanisms. By producing and characterizing P2RY4 in recombinant systems, researchers aim to dissect its interaction with ligands and downstream signaling pathways, paving the way for the development of novel therapeutic interventions. Furthermore, recombinant P2RY4 protein can serve as a valuable tool for drug discovery and screening assays, aiding in the identification of specific modulators that can enhance or inhibit its function. Understanding the nuances of P2RY4's role in cellular contexts will facilitate advancements in pharmacology and molecular medicine, ultimately contributing to improved strategies for managing diseases linked to purinergic signaling dysregulation.
