Analytical Data
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基因名
TACR3
- Application
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别名
TACR3；NK3R；TAC3R；Neuromedin-K receptor
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P29371
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表达区间
1-465aa
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氨基酸序列
MATLPAAETWIDGGGGVGADAVNLTASLAAGAATGAVETGWLQLLDQAGNLSSSPSALGLPVASPAPSQPWANLTNQFVQPSWRIALWSLAYGVVVAVAVLGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLVNFIYALHSEWYFGANYCRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPLKPRLSATATKIVIGSIWILAFLLAFPQCLYSKTKVMPGRTLCFVQWPEGPKQHFTYHIIVIILVYCFPLLIMGITYTIVGITLWGGEIPGDTCDKYHEQLKAKRKVVKMMIIVVMTFAICWLPYHIYFILTAIYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGFKRAFRWCPFIKVSSYDELELKTTRFHPNRQSSMYTVTRMESMTVVFDPNDADTTRSSRKKRATPRDPSFNGCSRRNSKSASATSSFISSPYTSVDEYS
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分子量
52.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TACR3, or Tachykinin receptor 3, is a crucial neurokinin receptor that plays a significant role in various physiological processes, including pain perception, neuroinflammation, and reproductive functions. This receptor is primarily activated by tachykinins such as neurokinin B (NKB), which are involved in modulating many central and peripheral nervous system functions. Research into TACR3 has gained prominence due to its potential implications in various diseases, including migraine, schizophrenia, and hypothalamic disorders related to energy homeostasis and reproductive health. The expression and signaling mechanisms of TACR3 remain complex, necessitating the need for recombinant protein studies that can provide deeper insights into its structure and function. The production of TACR3 recombinant proteins allows researchers to investigate its binding affinities, signaling pathways, and interactions with other proteins. Furthermore, understanding TACR3's role in cellular responses can aid in the development of targeted therapies for conditions where this receptor is implicated. As such, research efforts are focused not only on the biochemical characterization of TACR3 but also on its potential as a therapeutic target, underscoring its significance in neurobiology and pharmacology. The exploration of TACR3 through recombinant protein technologies thus represents a promising avenue for advancing our understanding of its biological roles and developing effective interventions in related pathologies.
