Analytical Data
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基因名
TCF4
- Application
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别名
TCF4；BHLHB19；Transcription factor 4
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P15884
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表达区间
1-507aa
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氨基酸序列
MGSSHHHHHH SSGLVPRGSH MGSMKFKQCR CSDTGLCCLD HEGKAEVYAP SASTADYNRD SPGYPSSKPA TSTFPSSFFM QDGHHSSDPW SSSSGMNQPG YAGMLGNSSH IPQSSSYCSL HPHERLSYPS HSSADINSSL PPMSTFHRSG TNHYSTSSCT PPANGTDSIM ANRGSGAAGS SQTGDALGKA LASIYSPDHT NNSFSSNPST PVGSPPSLSA GTAVWSRNGG QASSSPNYEG PLHSLQSRIE DRLERLDDAI HVLRNHAVGP STAMPGGHGD MHGIIGPSHN GAMGGLGSGY GTGLLSANRH SLMVGTHRED GVALRGSHSL LPNQVPVPQL PVQSATSPDL NPPQDPYRGM PPGLQGQSVS SGSSEIKSDD EGDENLQDTK SSEDKKLDDD KKDIKSITSN NDDEDLTPEQ KAEREKERRM ANNARERLRV RDINEAFKEL GRMVQLHLKS DKPQTKLLIL HQAVAVILSL EQQVRERNLN PKAACLKRRE EEKVSSEPPP LSLAGPHPGM GDASNHMGQM
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分子量
57 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TCF4, or Transcription Factor 4, is a member of the β-catenin/T cell factor (TCF) family of transcription factors, predominantly involved in the Wnt signaling pathway, which is crucial for various cellular processes, including cell proliferation, differentiation, and apoptosis. Research on TCF4 has gained significance due to its implications in developmental biology and its association with several psychiatric disorders, notably schizophrenia. The gene encoding TCF4 is located on chromosome 18, and polymorphisms within this gene have been linked to increased risk of psychiatric diseases, suggesting that TCF4 may play a vital role in neurodevelopmental processes. Moreover, TCF4 has been identified as a key regulator in the pathogenesis of various cancers, highlighting its dual role in both normal development and disease states. The study of TCF4 recombinant proteins has emerged as a valuable tool to understand its functional mechanisms, interactions with other proteins, and impact on gene expression. By producing TCF4 in recombinant forms, researchers can explore its binding affinities, post-translational modifications, and regulatory functions in vitro, thereby elucidating its role in cellular signaling pathways. Insights gained from the investigation of TCF4 recombinant proteins not only enhance our understanding of its biological functions but also open avenues for therapeutic interventions in TCF4-related diseases, making it a focal point in current biomedical research.
