Analytical Data
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Gene name
SUMO1
- Application
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Alternative Names
SUMO1；SMT3C；Small ubiquitin-related modifier 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P63279
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Expression Region
1-157aa
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AA Sequence
MSGIALSRLAQERKAWRKDHPFGFVAVPTKNPDGTMNLMNWECAIPGKKGTPWEGGLFKLRMLFKDDYPSSPPKCKFEPPLFHPNVYPSGTVCLSILEEDKDWRPAITIKQILLGIQELLNEPNIQDPAQAEAYTIYCQNRVEYEKRVRAQAKKFAP
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Molecular Weight
44.9kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SUMO1 (Small Ubiquitin-like Modifier 1) is a crucial post-translational modification protein that regulates various cellular processes, including nuclear transport, transcriptional regulation, protein stability, and response to stress. Its unique ability to conjugate to target proteins modulates their function, localization, and interactions, thus playing a significant role in cellular homeostasis and signaling pathways. Dysregulation of SUMOylation has been implicated in numerous diseases, particularly cancer and neurodegenerative disorders, highlighting the necessity for a deeper understanding of its biological functions and mechanisms. The study of recombinant SUMO1 proteins facilitates the exploration of SUMOylation's role in protein dynamics and cellular responses. By producing SUMO1 in vitro, researchers can manipulate its expression, investigate its interaction with specific substrates, and analyze the consequential effects on various cellular functions. This research not only aids in elucidating the fundamental biology of SUMOylation but also opens new avenues for therapeutic strategies targeting SUMOylation pathways in disease contexts. Overall, SUMO1 recombinant protein studies serve as a pivotal component for advancing our knowledge of post-translational modifications and their implications in health and disease.
