Analytical Data
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Gene name
ODF1
- Application
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Alternative Names
ODF1；HSPB10；ODFP；Outer dense fiber Protein 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q14990
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Expression Region
1-250aa
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AA Sequence
MAALSCLLDS VRRDIKKVDR ELRQLRCIDE FSTRCLCDLY MHPYCCCDLH PYPYCLCYSK RSRSCGLCDL YPCCLCDYKL YCLRPSLRSL ERKAIRAIED EKRELAKLRR TTNRILASSC CSSNILGSVN VCGFEPDQVK VRVKDGKVCV SAERENRYDC LGSKKYSYMN ICKEFSLPPC VDEKDVTYSY GLGSCVKIES PCYPCTSPCS PCSPCSPCNP CSPCNPCSPY DPCNPCYPCG SRFSCRKMIL
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Molecular Weight
28.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ODF1 (Outer Dense Fiber 1) is a structural protein found in the outer dense fibers of mammalian sperm, playing a crucial role in sperm motility and overall fertility. Research on ODF1 has intensified due to its implications in male reproductive health and its potential as a biomarker for fertility issues. ODF1 is known to influence the integrity and stability of the axoneme, the core structure of the sperm tail, which is essential for flagellar movement. Studies suggest that mutations or dysregulation of ODF1 can lead to compromised sperm function, contributing to conditions such as asthenozoospermia (reduced sperm motility) and infertility. Additionally, ODF1 interacts with other proteins, making it a vital component of the sperm's structural framework. Investigating the expression patterns, post-translational modifications, and interactions of ODF1 in various species may provide insights into evolutionary adaptations in reproductive strategies. Given the increasing rates of male infertility globally, understanding ODF1's role in sperm biology could pave the way for novel therapeutic strategies and diagnostic tools aimed at enhancing male fertility. Furthermore, the study of ODF1 can also help elucidate the complexities of cellular architecture in other tissues, opening avenues for broader biological applications beyond reproductive health. Thus, ODF1 research not only contributes to reproductive biology but also offers potential insights into protein function and cellular organization across different biological systems.
