Analytical Data
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Gene name
KAT2B
- Application
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Alternative Names
KAT2B；PCAF；Histone acetyltransferase KAT2B
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q92831
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Expression Region
431-832aa
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AA Sequence
MTDSHVLEEAKKPRVMGDIPMELINEVMSTITDPAAMLGPETNFLSAHSA RDEAARLEERRGVIEFHVVGNSLNQKPNKKILMWLVGLQNVFSHQLPRMP KEYITRLVFDPKHKTLALIKDGRVIGGICFRMFPSQGFTEIVFCAVTSNE QVKGYGTHLMNHLKEYHIKHDILNFLTYADEYAIGYFKKQGFSKEIKIPK TKYVGYIKDYEGATLMGCELNPRIPYTEFSVIIKKQKEIIKKLIERKQAQ IRKVYPGLSCFKDGVRQIPIESIPGIRETGWKPSGKEKSKEPRDPDQLYS TLKSILQQVKSHQSAWPFMEPVKRTEAPGYYEVIRFPMDLKTMSERLKNR YYVSKKLFMADLQRVFTNCKEYNPPESEYYKCANILEKFFFSKIKEAGLI DK
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Molecular Weight
70 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
KAT2B, also known as LYSINE ACETYLTRANSFERASE 2B, is a member of the GCN5-related N-acetyltransferase (GNAT) family, which plays a crucial role in the post-translational modification of proteins through acetylation. This modification affects various cellular processes, including gene expression, cellular metabolism, and signal transduction. KAT2B has garnered attention for its involvement in several physiological and pathological conditions, such as cancer, metabolic disorders, and neurodegenerative diseases. Research has shown that KAT2B influences the transcriptional regulation of key genes by modifying histones and non-histone proteins, thereby impacting chromatin structure and function. Investigating KAT2B's role in these processes is vital for understanding the underlying mechanisms of diseases and developing potential therapeutic strategies. Recent advancements in recombinant protein technology have facilitated the production of KAT2B, allowing researchers to explore its structure, function, and interactions with other proteins. This research may lead to significant insights into the regulatory networks governed by acetylation and provide new avenues for drug discovery and development in treating disorders linked to dysregulated acetylation.
