Analytical Data
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Gene name
ADAD2
- Application
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Alternative Names
ADAD2; TENRLAdenosine deaminase domain-containing Protein 2; Testis nuclear RNA-binding Protein-like
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8NCV1
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Expression Region
1-583aa
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AA Sequence
MASASQGADD DGSRRKPRLA ASLQISPQPR PWRPLPAQAQ SAWGPAPAPA TYRAEGGWPQ VSVLRDSGPG AGAGVGELGA ARAWENLGEQ MGKAPRVPVP PAGLSLPLKD PPASQAVSLL TEYAASLGIF LLFREDQPPG PCFPFSVSAE LDGVVCPAGT ANSKTEAKQQ AALSALCYIR SQLENPESPQ TSSRPPLAPL SVENILTHEQ RCAALVSAGF DLLLDERSPY WACKGTVAGV ILEREIPRAR GHVKEIYKLV ALGTGSSCCA GWLEFSGQQL HDCHGLVIAR RALLRFLFRQ LLLATQGGPK GKEQSVLAPQ PGPGPPFTLK PRVFLHLYIS NTPKGAARDI YLPPTSEGGL PHSPPMRLQA HVLGQLKPVC YVAPSLCDTH VGCLSASDKL ARWAVLGLGG ALLAHLVSPL YSTSLILADS CHDPPTLSRA IHTRPCLDSV LGPCLPPPYV RTALHLFAGP PVAPSEPTPD TCRGLSLNWS LGDPGIEVVD VATGRVKANA ALGPPSRLCK ASFLRAFHQA ARAVGKPYLL ALKTYEAAKA GPYQEARRQL SLLLDQQGLG AWPSKPLVGK FRN
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Molecular Weight
61.7 KDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ADAD2 (Adenosine Deaminase Acting on RNA 2) is an important RNA-binding protein that plays a crucial role in the post-transcriptional regulation of gene expression. It is a member of the adenosine deaminase acting on RNA (ADAR) family, which is known for its modulation of RNA editing and influencing various biological processes, including the immune response and neuronal function. Research into ADAD2 is particularly significant due to its potential implications in human health and disease, particularly in neurological disorders and cancer. The misregulation or mutation of ADAD2 has been linked to various pathologies, underscoring the need for a deeper understanding of its function. Recombining ADAD2 into a functional protein provides a valuable tool for studying its molecular mechanisms and interactions within cells. By investigating the characteristics and activities of restored ADAD2, researchers aim to elucidate its role in RNA editing and the broader implications for gene regulation. This research not only enhances our understanding of ADAD2's biological significance but also offers potential therapeutic avenues for conditions associated with its dysfunction. The study of ADAD2 recombinant proteins has become an essential focus in molecular biology, promising to uncover new insights into RNA metabolism and therapeutic strategies for diseases linked to its dysregulation.
