Analytical Data
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基因名
CELSR1
- Application
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别名
CELSR1；CDHF9；FMI2；Cadherin EGF LAG seven-pass G-type receptor 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NYQ6
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表达区间
全长
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氨基酸序列
full
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分子量
329 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CELSR1 (Cadherin EGF LAG Seven-Pass G-Type Receptor 1) is a member of the CELSR family of proteins, known for their critical roles in cell signaling and tissue development. These proteins are characterized by their unique structure, which includes multiple cadherin repeats and seven transmembrane domains, suggesting functions in cell adhesion and communication. Research has shown that CELSR1 is involved in various biological processes, including neural development, where it plays a vital role in planar cell polarity and axon guidance. Mutations in the CELSR1 gene have been associated with a range of developmental disorders, including neural tube defects and cardiac anomalies, making it a significant target for studying congenital malformations. Moreover, due to its involvement in key signaling pathways, CELSR1 has garnered attention in cancer research, particularly in understanding tumor microenvironments and metastasis. The recombination and production of CELSR1 protein provide essential tools for elucidating its molecular mechanisms and interactions in cell signaling. Thus, the study of CELSR1 recombinant protein not only enhances our understanding of developmental biology but also holds potential implications for therapeutic strategies in managing congenital disorders and cancers.
