Analytical Data
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Gene name
CELSR1
- Application
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Alternative Names
CELSR1；CDHF9；FMI2；Cadherin EGF LAG seven-pass G-type receptor 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NYQ6
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Expression Region
全长
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AA Sequence
full
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Molecular Weight
329 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CELSR1 (Cadherin EGF LAG Seven-Pass G-Type Receptor 1) is a member of the CELSR family of proteins, known for their critical roles in cell signaling and tissue development. These proteins are characterized by their unique structure, which includes multiple cadherin repeats and seven transmembrane domains, suggesting functions in cell adhesion and communication. Research has shown that CELSR1 is involved in various biological processes, including neural development, where it plays a vital role in planar cell polarity and axon guidance. Mutations in the CELSR1 gene have been associated with a range of developmental disorders, including neural tube defects and cardiac anomalies, making it a significant target for studying congenital malformations. Moreover, due to its involvement in key signaling pathways, CELSR1 has garnered attention in cancer research, particularly in understanding tumor microenvironments and metastasis. The recombination and production of CELSR1 protein provide essential tools for elucidating its molecular mechanisms and interactions in cell signaling. Thus, the study of CELSR1 recombinant protein not only enhances our understanding of developmental biology but also holds potential implications for therapeutic strategies in managing congenital disorders and cancers.
