Analytical Data
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基因名
NUP43
- Application
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别名
NUP43Nucleoporin Nup43; Nup107-160 subcomplex subunit Nup43; p42
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8NFH3
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表达区间
1-380 aa
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氨基酸序列
MEEIYAKFVS QKISKTRWRP LPPGSLQTAE TFATGSWDNE ENYISLWSIG DFGNLDSDGG FEGDHQLLCD IRHHGDVMDL QFFDQERIVA ASSTGCVTVF LHHPNNQTLS VNQQWTTAHY HTGPGSPSYS SAPCTGVVCN NPEIVTVGED GRINLFRADH KEAVRTIDNA DSSTLHAVTF LRTPEILTVN SIGQLKIWDF RQQGNEPSQI LSLTGDRVPL HCVDRHPNQQ HVVATGGQDG MLSIWDVRQG TMPVSLLKAH EAEMWEVHFH PSNPEHLFTC SEDGSLWHWD ASTDVPEKSS LFHQGGRSST FLSHSISNQA NVHQSVISSW LSTDPAKDRI EITSLLPSRS LSVNTLDVLG PCLVCGTDAE AIYVTRHLFS
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分子量
42.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NUP43 is a member of the nuclear pore complex (NPC) protein family, playing a crucial role in nucleocytoplasmic transport and maintaining nuclear envelope integrity. Research on NUP43 recombinant proteins has gained importance due to their involvement in essential cellular processes, such as gene expression regulation and signal transduction. Disruptions in NUP43 function have been implicated in various diseases, including cancer, highlighting the need for a better understanding of its biological roles and mechanisms. The study of NUP43 recombinant proteins allows researchers to investigate their structure-function relationships, interactions with other nucleoporins, and impact on nuclear transport pathways. Additionally, exploring NUP43 could provide insights into the molecular basis of nuclear transport disorders and aid in the identification of potential therapeutic targets. By employing techniques such as X-ray crystallography, nuclear magnetic resonance (NMR), and cryo-electron microscopy, researchers can elucidate the three-dimensional structures of NUP43 and its complexes, paving the way for developing strategies to modulate its activity in pathological conditions. Overall, NUP43 recombinant protein research advances our understanding of nuclear transport mechanisms, molecular pathogenesis, and potential interventions for diseases linked to nucleoporins.
