Analytical Data
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基因名
NUMBL
- Application
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别名
CAG 3A; CAG3A; CTG 3a; CTG3a; NBL; NUMB Drosophilia Homolog Like; Numb homolog (Drosophila) like; Numb homolog like; Numb like protein; NUMB R; Numb-like protein; Numb-R; Numb-related gene; Numb-related protein; NUMBL; NUMBL_HUMAN; NUMBLIKE; NUMBR; TNRC 23; TNRC23; Trinucleotide repeat-containing gene 23
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Y6R0
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表达区间
1-609 aa
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氨基酸序列
MSRSAAASGG PRRPERHLPP APCGAPGPPE TCRTEPDGAG TMNKLRQSLR RRKPAYVPEA SRPHQWQADE DAVRKGTCSF PVRYLGHVEV EESRGMHVCE DAVKKLKAMG RKSVKSVLWV SADGLRVVDD KTKDLLVDQT IEKVSFCAPD RNLDKAFSYI CRDGTTRRWI CHCFLALKDS GERLSHAVGC AFAACLERKQ RREKECGVTA AFDASRTSFA REGSFRLSGG GRPAEREAPD KKKAEAAAAP TVAPGPAQPG HVSPTPATTS PGEKGEAGTP VAAGTTAAAI PRRHAPLEQL VRQGSFRGFP ALSQKNSPFK RQLSLRLNEL PSTLQRRTDF QVKGTVPEME PPGAGDSDSI NALCTQISSS FASAGAPAPG PPPATTGTSA WGEPSVPPAA AFQPGHKRTP SEAERWLEEV SQVAKAQQQQ QQQQQQQQQQ QQQQQQAASV APVPTMPPAL QPFPAPVGPF DAAPAQVAVF LPPPHMQPPF VPAYPGLGYP PMPRVPVVGI TPSQMVANAF CSAAQLQPQP ATLLGKAGAF PPPAIPSAPG SQARPRPNGA PWPPEPAPAP APELDPFEAQ WAALEGKATV EKPSNPFSGD LQKTFEIEL
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分子量
64.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NUMBL (Numb-like protein) is a crucial member of the NUMB family, known for its role in cell fate determination and asymmetric cell division. Research on NUMBL has gained momentum due to its implications in various developmental processes and diseases. NUMBL is believed to interact with several signaling pathways and transcription factors, influencing not only neurogenesis but also stem cell maintenance and differentiation. Abnormal regulation of NUMBL has been linked to various cancers and neurodegenerative disorders, underscoring its importance in both developmental biology and pathology. Recent studies have focused on understanding the structural properties and functional domains of NUMBL, aiming to elucidate its mechanism of action in cellular contexts. Experimental approaches, including protein expression and purification, have allowed researchers to investigate NUMBL's interactions and modifications at the molecular level. Insights gained from NUMBL research could pave the way for novel therapeutic strategies targeting its dysfunctional pathways in disease states, highlighting the protein's significance in both fundamental biology and clinical applications.
