Analytical Data
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基因名
NPEPL1
- Application
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别名
Aminopeptidase like 1 ; Aminopeptidase-like 1; bA261P9.2; KIAA1974; NPEPL 1; NPEPL1; PEPL1_HUMAN; Probable aminopeptidase NPEPL1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8NDH3
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表达区间
1-523 aa
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氨基酸序列
MANVGLQFQA SAGDSDPQSR PLLLLGQLHH LHRVPWSHVR GKLQPRVTEE LWQAALSTLN PNPTDSCPLY LNYATVAALP CRVSRHNSPS AAHFITRLVR TCLPPGAHRC IVMVCEQPEV FASACALARA FPLFTHRSGA SRRLEKKTVT VEFFLVGQDN GPVEVSTLQC LANATDGVRL AARIVDTPCN EMNTDTFLEE INKVGKELGI IPTIIRDEEL KTRGFGGIYG VGKAALHPPA LAVLSHTPDG ATQTIAWVGK GIVYDTGGLS IKGKTTMPGM KRDCGGAAAV LGAFRAAIKQ GFKDNLHAVF CLAENSVGPN ATRPDDIHLL YSGKTVEINN TDAEGRLVLA DGVSYACKDL GADIILDMAT LTGAQGIATG KYHAAVLTNS AEWEAACVKA GRKCGDLVHP LVYCPELHFS EFTSAVADMK NSVADRDNSP SSCAGLFIAS HIGFDWPGVW VHLDIAAPVH AGERATGFGV ALLLALFGRA SEDPLLNLVS PLGCEVDVEE GDLGRDSKRR RLV
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分子量
55.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NPEPL1 (Neutral Peptidase Like 1) is a cytosolic enzyme belonging to the M48 peptidase family, primarily involved in the hydrolysis of bioactive peptides and potentially in cellular signaling pathways. The study of NPEPL1 has gained significance due to its implications in various physiological and pathological processes, including metabolism, neurodegeneration, and cancer. Recent research has highlighted its role in regulating peptide levels, which can influence inflammation and neuroprotective mechanisms. NPEPL1 is also thought to be involved in the degradation of misfolded proteins and peptides, linking it to protein homeostasis and cellular stress responses. The generation of recombinant NPEPL1 protein allows for in-depth biochemical characterization and functional assays, facilitating the understanding of its substrate specificity and catalytic mechanisms. Moreover, studying its interactions with other cellular components can provide insights into its biological functions and therapeutic potential. The recombinant expression systems utilized for NPEPL1 also contribute to the development of specific inhibitors or modulators that may offer novel approaches in treating diseases associated with its dysregulation. Thus, the research on NPEPL1 recombinant protein is crucial for unraveling its role in health and disease, paving the way for future therapeutic developments targeting this enzyme.
