Analytical Data
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Gene name
NKX2-3
- Application
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Alternative Names
NKX2-3; NKX23; NKX2CHomeobox protein Nkx-2.3; Homeobox protein NK-2 homolog C
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8TAU0
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Expression Region
1-364 aa
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AA Sequence
MMLPSPVTST PFSVKDILNL EQQHQHFHGA HLQADLEHHF HSAPCMLAAA EGTQFSDGGE EDEEDEGEKL SYLNSLAAAD GHGDSGLCPQ GYVHTVLRDS CSEPKEHEEE PEVVRDRSQK SCQLKKSLET AGDCKAAEES ERPKPRSRRK PRVLFSQAQV FELERRFKQQ RYLSAPEREH LASSLKLTST QVKIWFQNRR YKCKRQRQDK SLELGAHAPP PPPRRVAVPV LVRDGKPCVT PSAQAYGAPY SVGASAYSYN SFPAYGYGNS AAAAAAAAAA AAAAAAYSSS YGCAYPAGGG GGGGGTSAAT TAMQPACSAA GGGPFVNVSN LGGFGSGGSA QPLHQGTAAG AACAQGTLQG IRAW
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Molecular Weight
38.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NKX2-3 is a member of the NK-2 family of transcription factors, which play crucial roles in developmental processes and tissue-specific gene regulation. Initially identified for its involvement in the development of the gastrointestinal tract and the immune system, NKX2-3 has garnered attention for its potential implications in various diseases, including inflammatory bowel disease and certain cancers. Recent studies have begun to elucidate the mechanisms by which NKX2-3 influences cellular function, highlighting its role in regulating immune responses and maintaining gut homeostasis. The recombinant expression of NKX2-3 protein provides a valuable tool for investigating its biological functions and interactions in vitro and in vivo. Researchers have been focusing on the structural characterization of NKX2-3 to understand its DNA-binding properties and regulatory networks better. Furthermore, the study of NKX2-3 is paving the way for developing therapeutic strategies aimed at modulating its activity, making it a significant target for future research in regenerative medicine and disease treatment. Overall, the ongoing exploration of NKX2-3 and its recombinant protein is expected to yield insights that could transform our understanding of developmental biology and disease mechanisms.
