Analytical Data
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Gene name
RTCA
- Application
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Alternative Names
RTCA;RPC;RPC1;RTC1;RNA 3'-terminal phosphate cyclase
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O00442
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Expression Region
1-366aa
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AA Sequence
MGSSHHHHHHSSGLVPRGSHMGSMAGPRVEVDGSIMEGGGQILRVSTALS CLLGLPLRVQKIRAGRSTPGLRPQHLSGLEMIRDLCDGQLEGAEIGSTEI TFTPEKIKGGIHTADTKTAGSVCLLMQVSMPCVLFAASPSELHLKGGTNA EMAPQIDYTVMVFKPIVEKFGFIFNCDIKTRGYYPKGGGEVIVRMSPVKQ LNPINLTERGCVTKIYGRAFVAGVLPFKVAKDMAAAAVRCIRKEIRDLYV NIQPVQEPKDQAFGNGNGIIIIAETSTGCLFAGSSLGKRGVNADKVGIEA AEMLLANLRHGGTVDEYLQDQLIVFMALANGVSRIKTGPVTLHTQTAIHF AEQIAKAKFIVKKSEDEEDAAKDTYIIECQGIGMTNPNL
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Molecular Weight
42 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
RTCA (Regulatory T Cell Antigen) is a protein that plays a pivotal role in the immune system, particularly in the function and development of regulatory T cells (Tregs). Tregs are crucial for maintaining immune homeostasis and preventing autoimmunity by modulating the activity of other immune cells. Research into RTCA has gained importance due to its potential implications in autoimmune diseases, cancer immunotherapy, and transplantation. Understanding the mechanisms by which RTCA influences Treg function could uncover new therapeutic targets for enhancing immune tolerance and developing effective treatments. Furthermore, the ability to produce recombinant RTCA protein offers the opportunity to study its structure-function relationship and interactions with other immune molecules. As the field of immunology continues to evolve, investigating the role of RTCA and its potential as a biomarker or therapeutic agent represents a promising avenue for future research, aiming to elucidate the complexities of immune regulation and pave the way for novel interventions in immune-related disorders.
