Analytical Data
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Gene name
MRPS27
- Application
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Alternative Names
28S ribosomal protein S27; 28S ribosomal protein S27. mitochondrial; KIAA0264; Mitochondrial 28S ribosomal protein S27; mitochondrial; mitochondrial ribosomal protein S27; MRP-S27; MRPS27; RT27_HUMAN; S27mt
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q92552
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Expression Region
1-414 aa
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AA Sequence
MAASIVRRGM LLARQVVLPQ LSPAGKRYLL SSAYVDSHKW EAREKEHYCL ADLASLMDKT FERKLPVSSL TISRLIDNIS SREEIDHAEY YLYKFRHSPN CWYLRNWTIH TWIRQCLKYD AQDKALYTLV NKVQYGIFPD NFTFNLLMDS FIKKENYKDA LSVVFEVMMQ EAFEVPSTQL LSLYVLFHCL AKKTDFSWEE ERNFGASLLL PGLKQKNSVG FSSQLYGYAL LGKVELQQGL RAVYHNMPLI WKPGYLDRAL QVMEKVAASP EDIKLCREAL DVLGAVLKAL TSADGASEEQ SQNDEDNQGS EKLVEQLDIE ETEQSKLPQY LERFKALHSK LQALGKIESE GLLSLTTQLV KEKLSTCEAE DIATYEQNLQ QWHLDLVQLI QREQQQREQA KQEYQAQKAA KASA
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Molecular Weight
47.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MRPS27, or Mitochondrial Ribosomal Protein S27, is a vital component of the mitochondrial ribosome, playing a crucial role in mitochondrial protein synthesis, which is essential for cellular energy production. Research has shown that mitochondrial dysfunction is implicated in various diseases, including neurodegenerative disorders, metabolic syndromes, and certain types of cancer. The understanding of MRPS27's function and regulation has gained significance due to its potential impact on mitochondrial biogenesis and disease progression. Studies suggest that alterations in MRPS27 expression can significantly affect mitochondrial translation efficiency and overall cellular health. Furthermore, recent investigations have highlighted its involvement in oxidative stress response and apoptosis, leading to increased interest in MRPS27 as a therapeutic target. Characterizing this recombinant protein provides insights into its structural and functional properties, helping to elucidate its role in mitochondrial dynamics and pathology. The exploration of MRPS27 not only deepens our understanding of mitochondrial biology but also opens avenues for novel interventions in diseases linked to mitochondrial dysfunction. Overall, MRPS27 emerges as a promising candidate for both basic research and clinical applications in improving mitochondrial health and combating related disorders.
