Analytical Data
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基因名
catD
- Application
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别名
catD；CPSD；Cathepsin D
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P11504
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表达区间
1-212aa
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氨基酸序列
MVFEKIDKNSWNRKEYFDHYFASVPCTYSMTVKVDITQIKEKGMKLYPAMLYYIAMIVNRHSEFRTAINQDGELGIYDEMIPSYTIFHNDTETFSSLWTECKSDFKSFLADYESDTQRYGNNHRMEGKPNAPENIFNVSMIPWSTFDGFNLNLQKGYDYLIPIFTMGKIIKKDNKIILPLAIQVHHAVCDGFHICRFVNELQELIIVTQVCL
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分子量
32.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CatD, or Cathepsin D, is an aspartic protease that plays a crucial role in various physiological and pathological processes, including protein degradation, antigen processing, and apoptosis. Originally identified for its involvement in lysosomal function, CatD has gained attention for its implications in cancer biology, as its overexpression is often associated with tumor progression and metastasis. Research has shown that CatD contributes to the degradation of the extracellular matrix, facilitating cancer cell invasion and migration. Additionally, its role in the immune response highlights its importance in modulating inflammatory processes. The study of recombinant CatD proteins has provided insights into its structure-function relationships and potential therapeutic applications, including the development of inhibitors targeting its proteolytic activity. These inhibitors could serve as novel anticancer agents, making CatD a significant focus in both basic and translational research. Understanding the dynamics of CatD, including its regulation and interactions with other cellular components, continues to be a key area of interest, as it offers potential avenues for innovative treatments in cancer and other diseases where dysregulation of proteolytic activity is observed.
