Analytical Data
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Gene name
gABRa1
- Application
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Alternative Names
gABRa1；Gamma-aminobutyric acid receptor subunit alpha-1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P14867
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Expression Region
28-251aa
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AA Sequence
QPSLQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIG
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Molecular Weight
29.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The study of the GABRA1 recombinant protein is rooted in the growing understanding of the GABAergic system, which plays a critical role in neurotransmission and the regulation of neuronal excitability in the brain. GABRA1 encodes the alpha-1 subunit of the GABA type A receptor, a key component in mediating the inhibitory effects of gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter. Mutations in the GABRA1 gene have been linked to various neurological disorders, including epilepsy and intellectual disabilities, highlighting the importance of this protein in maintaining synaptic balance. Researchers have sought to produce recombinant GABRA1 protein to facilitate studies on its structural and functional properties, enabling a deeper understanding of receptor dynamics, pharmacological interactions, and the molecular mechanisms underlying GABAergic signaling. Additionally, recombinant protein studies can help in drug development aimed at modulating GABA receptor activity, which is crucial for devising therapeutic strategies for conditions characterized by dysregulated GABA signaling. Overall, the exploration of GABRA1 recombinant protein is vital for advancing our knowledge of neurobiology and developing potential treatments for related disorders.
