Analytical Data
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基因名
gABRa1
- Application
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别名
gABRa1；Gamma-aminobutyric acid receptor subunit alpha-1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P14867
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表达区间
28-251aa
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氨基酸序列
QPSLQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIG
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分子量
29.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The study of the GABRA1 recombinant protein is rooted in the growing understanding of the GABAergic system, which plays a critical role in neurotransmission and the regulation of neuronal excitability in the brain. GABRA1 encodes the alpha-1 subunit of the GABA type A receptor, a key component in mediating the inhibitory effects of gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter. Mutations in the GABRA1 gene have been linked to various neurological disorders, including epilepsy and intellectual disabilities, highlighting the importance of this protein in maintaining synaptic balance. Researchers have sought to produce recombinant GABRA1 protein to facilitate studies on its structural and functional properties, enabling a deeper understanding of receptor dynamics, pharmacological interactions, and the molecular mechanisms underlying GABAergic signaling. Additionally, recombinant protein studies can help in drug development aimed at modulating GABA receptor activity, which is crucial for devising therapeutic strategies for conditions characterized by dysregulated GABA signaling. Overall, the exploration of GABRA1 recombinant protein is vital for advancing our knowledge of neurobiology and developing potential treatments for related disorders.
