Analytical Data
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Gene name
MPP3
- Application
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Alternative Names
MPP3；DLG3；MAGUK p55 subfamily member 3
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P08254
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Expression Region
101-477aa
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AA Sequence
MRTFPGIPKW RKTHLTYRIV NYTPDLPKDA VDSAVEKALK VWEEVTPLTF SRLYEGEADI MISFAVREHG DFYPFDGPGN VLAHAYAPGP GINGDAHFDD DEQWTKDTTG TNLFLVAAHE IGHSLGLFHS ANTEALMYPL YHSLTDLTRF RLSQDDINGI QSLYGPPPDS PETPLVPTEP VPPEPGTPAN CDPALSFDAV STLRGEILIF KDRHFWRKSL RKLEPELHLI SSFWPSLPSG VDAAYEVTSK DLVFIFKGNQ FWAIRGNEVR AGYPRGIHTL GFPPTVRKID AAISDKEKNK TYFFVEDKYW RFDEKRNSME PGFPKQIAED FPGIDSKIDA VFEEFGFFYF FTGSSQLEFD PNAKKVTHTL KSNSWLNC
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Molecular Weight
43 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MPP3, a member of the membrane-associated guanylate kinase (MAGUK) family, plays a crucial role in the organization and maintenance of protein complexes at cell junctions, particularly in neuronal tissues and epithelial cells. It is characterized by its multiple protein-protein interaction domains, which facilitate its involvement in signaling pathways and cellular adhesion. Research on MPP3 has gained momentum due to its potential implications in various physiological processes, including synaptic function, cell polarization, and the maintenance of the blood-brain barrier. Dysregulation or mutations in the MPP3 gene have been linked to several neurodevelopmental and psychiatric disorders, highlighting its importance in brain health. Moreover, understanding the molecular mechanisms underlying MPP3's function could provide insights into the pathogenesis of such conditions, paving the way for potential therapeutic interventions. Recent studies have employed advanced techniques, such as CRISPR-Cas9 gene editing and high-resolution microscopy, to elucidate MPP3's role in cellular contexts. Additionally, MPP3's interaction with other MAGUK family members and its impact on cellular dynamics make it a compelling subject for ongoing research in the realms of cell biology and neuroscience. The growing body of evidence surrounding MPP3 suggests that it is not only vital for basic cellular functions but also integral to understanding complex neurological diseases, marking it as a significant focus in biomedical research.
