Analytical Data
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基因名
LATS1
- Application
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别名
LATS1；WARTS；Serine/threonine-Protein kinase LATS1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O95835
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表达区间
705-1090aa
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氨基酸序列
FVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPESLARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSNEWGDPSSCRCGDRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILFEMLVGQPPFLAQTPLETQMKVINWQTSLHIPPQAKLSPEASDLIIKLCRGPEDRLGKNGADEIKAHPFFKTIDFSSDLRQQSASYIPKITHPTDTSNFDPVDPDKLWSDDNEEENVNDTLNGWYKNGKHPEHAFYEFTFRRFFDDNGYP
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分子量
49.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LATS1 (Large Tumor Suppressor 1) is a crucial protein in the Hippo signaling pathway, which plays a significant role in regulating cell growth, proliferation, and apoptosis. Dysregulation of this pathway has been implicated in various cancers, making LATS1 a key focus for cancer research. Studies have shown that LATS1 functions as a tumor suppressor by inhibiting cell cycle progression and promoting apoptosis in response to cellular stress. Its role in maintaining tissue homeostasis and organ size has further highlighted its importance in developmental biology. Given the tumor-suppressive properties of LATS1, researchers are investigating its potential as a therapeutic target for cancer treatment. The recombination and expression of LATS1 allow for detailed studies on its structure, function, and interaction with other proteins in the Hippo pathway. Advances in recombinant protein techniques are aiding the production of LATS1 for biochemical assays, aiding in the elucidation of its mechanistic roles in cancer biology. Understanding the functional dynamics of LATS1 is essential for the development of novel cancer therapies that can effectively leverage the Hippo signaling pathway for tumor growth inhibition.
