Analytical Data
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基因名
MARK2
- Application
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别名
ELKL motif kinase 1; ELKL motif kinase; EMK-1; EMK1; MAP/microtubule affinity regulating kinase 2; MAP/microtubule affinity-regulating kinase 2; Mark2; MARK2_HUMAN; MGC99619; PAR 1; Par 1b; PAR1 homolog; Par1b; Ser/Thr protein kinase PAR 1B; Serine/threonine protein kinase EMK; Serine/threonine protein kinase MARK2; Serine/threonine-protein kinase MARK2
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q7KZI7
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表达区间
1-755aa
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氨基酸序列
MIRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSLTMPGSRASTASASAAVSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFRFARRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIANELKL
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分子量
110.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MARK2 (Microtubule Affinity Regulating Kinase 2) is a serine/threonine kinase that plays a crucial role in various cellular processes, including microtubule dynamics, cell cycle regulation, and neuronal differentiation. As a member of the MARK family, MARK2 is particularly known for its involvement in the phosphorylation of tau protein, which is significant in the context of neurodegenerative diseases such as Alzheimer's. The dysregulation of MARK2 activity has been implicated in various pathophysiological conditions, highlighting its potential as a therapeutic target. Research into MARK2 recombination proteins has gained momentum as scientists aim to elucidate its precise mechanisms of action and regulatory pathways. This includes investigations into how MARK2 influences microtubule stability and cytoskeletal organization, which are vital for maintaining cellular integrity and function. Furthermore, recombinant MARK2 proteins are being utilized in biochemical assays to screen for inhibitors that could modulate its activity, providing insights into potential drug development avenues. Overall, the study of MARK2 recombination proteins is pivotal for advancing our understanding of cellular mechanisms and the development of innovative strategies to address diseases linked to microtubule dysregulation.
