Analytical Data
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基因名
KRT14
- Application
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别名
KRT14；Keratin. type I cytoskeletal 14
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P02533
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表达区间
1-472aa
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氨基酸序列
MTTCSRQFTSSSSMKGSCGIGGGIGGGSSRISSVLAGGSCRAPSTYGGGLSVSSSRFSSGGACGLGGGYGGGFSSSSSSFGSGFGGGYGGGLGAGLGGGFGGGFAGGDGLLVGSEKVTMQNLNDRLASYLDKVRALEEANADLEVKIRDWYQRQRPAEIKDYSPYFKTIEDLRNKILTATVDNANVLLQIDNARLAADDFRTKYETELNLRMSVEADINGLRRVLDELTLARADLEMQIESLKEELAYLKKNHEEEMNALRGQVGGDVNVEMDAAPGVDLSRILNEMRDQYEKMAEKNRKDAEEWFFTKTEELNREVATNSELVQSGKSEISELRRTMQNLEIELQSQLSMKASLENSLEETKGRYCMQLAQIQEMIGSVEEQLAQLRCEMEQQNQEYKILLDVKTRLEQEIATYRRLLEGEDAHLSSSQFSSGSQSSRDVTSSSRQIRTKVMDVHDGKVVSTHEQVLRTKN
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分子量
53.6kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KRT14, or Keratin 14, is a type I keratin that plays a crucial role in maintaining the structural integrity and functionality of epithelial tissues, particularly in the skin. Abnormal expression or mutations in the KRT14 gene can lead to various skin disorders, including epidermolysis bullosa simplex, a condition characterized by increased skin fragility and susceptibility to blistering. As a significant component of the intermediate filament network, KRT14 contributes to cell resilience against mechanical stress, making it essential for the proper development and maintenance of the epidermis. The study of KRT14 recombinant protein has gained momentum in recent years, driven by the need to better understand its molecular functions, interactions, and regulatory mechanisms. Producing KRT14 as a recombinant protein enables researchers to study its biophysical properties, elucidate its role in keratinocyte biology, and explore potential therapeutic applications for skin-related diseases. Additionally, KRT14 recombinant protein serves as a valuable tool for developing diagnostic markers and treatment strategies, enhancing our understanding of keratinocyte differentiation, wound healing, and the molecular underpinnings of skin pathologies. Overall, KRT14 remains a focal point of research in dermatological studies, with implications that extend to regenerative medicine and gene therapy.
