Analytical Data
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基因名
PAK4
- Application
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别名
PAK4;KIAA1142;Serine/threonine-Protein kinase PAK 4
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O96013
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表达区间
1-426aa
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氨基酸序列
MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACITSIQPGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENGMPEKPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRTR
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分子量
63.9kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PAK4 (p21-activated kinase 4) is a serine/threonine kinase that belongs to the PAK family of proteins, which are critical modulators of a variety of cellular processes including cytoskeletal dynamics, cell migration, and proliferation. Research into PAK4 has gained momentum due to its significant role in cancer biology; it is frequently overexpressed in various human malignancies, particularly in breast, prostate, and ovarian cancers. PAK4 is involved in signaling pathways that regulate cell survival and motility, contributing to tumor growth and metastasis. The kinase has been implicated in the modulation of actin cytoskeleton, providing a mechanistic link to processes such as cell adhesion and migration, which are fundamental to cancer progression. Additionally, PAK4 has been identified as a potential therapeutic target due to its association with oncogenic pathways. Efforts to develop PAK4 inhibitors are underway, aiming to mitigate its pro-tumorigenic effects and enhance the efficacy of existing cancer treatments. Understanding the structure, function, and regulatory mechanisms of PAK4 is essential for elucidating its impact on tumor biology and for the development of novel therapeutic interventions. Thus, the study of PAK4 recombinant proteins not only helps to unravel the complexities of cancer signaling pathways but also opens new avenues for targeted cancer therapies.
