Analytical Data
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基因名
OSCAR
- Application
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别名
OSCAR;Osteoclast-associated immunoglobulin-like receptor
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8IYS5-7
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表达区间
19-286aa
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氨基酸序列
MGSSHHHHHH SSGLVPRGSH MGSDITPSVA IIVPPASYHP KPWLGAQPAT VVTPGVNVTL RCRAPQPAWR FGLFKPGEIA PLLFRDVSSE LAEFFLEEVT PAQGGIYRCC YRRPDWGPGV WSQPSDVLEL LVTEELPRPS LVALPGPVVG PGANVSLRCA GRLRNMSFVL YREGVAAPLQ YRHSAQPWAD FTLLGARAPG TYSCYYHTPS APYVLSQRSE VLVISWEGEG PEARPASSAP GMQAPGPPPS DPGAQAPSLS SFRPRGLVLQ PLLPQTQDSW DPAPPPSDPG V
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分子量
31 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
OSCAR (osteoclast-associated immunoglobulin-like receptor) is a novel protein that plays a crucial role in the regulation of osteoclast function and bone homeostasis. Found primarily on the surface of osteoclasts, OSCAR is implicated in the signaling pathways that mediate bone resorption, making it a significant target for understanding bone-related diseases such as osteoporosis and rheumatoid arthritis. Research into OSCAR has gained momentum due to its unique immunoglobulin-like structure, which suggests potential roles in modulating immune responses in the bone microenvironment. Studies have shown that OSCAR can interact with various ligands, contributing to the regulation of osteoclastogenesis and the activity of bone-resorbing cells. Investigating OSCAR's molecular mechanisms and its interactions can lead to insights into osteoclast differentiation and activity, potentially informing the development of therapeutic strategies aimed at preventing excessive bone loss. Additionally, understanding OSCAR's role in systemic inflammation opens avenues for exploring its impact beyond the skeletal system, linking bone health to overall immune function. As a focal point in current osteoimmunology research, OSCAR represents a promising target for novel treatments aimed at restoring bone integrity and managing metabolic bone diseases.
