Analytical Data
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基因名
GRIK2
- Application
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别名
GRIK2；GLUR6；Glutamate receptor ionotropic. kainate 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q13002-5
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表达区间
1-561aa
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氨基酸序列
MKIIFPILSN PVFRRTVKLL LCLLWIGYSQ GTTHVLRFGG IFEYVESGPM GAEELAFRFA VNTINRNRTL LPNTTLTYDT QKINLYDSFE ASKKACDQLS LGVAAIFGPS HSSSANAVQS ICNALGVPHI QTRWKHQVSD NKDSFYVSLY PDFSSLSRAI LDLVQFFKWK TVTVVYDDST GLIRLQELIK APSRYNLRLK IRQLPADTKD AKPLLKEMKR GKEFHVIFDC SHEMAAGILK QALAMGMMTE YYHYIFTTLD LFALDVEPYR YSGVNMTGFR ILNTENTQVS SIIEKWSMER LQAPPKPDSG LLDGFMTTDA ALMYDAVHVV SVAVQQFPQM TVSSLQCNRH KPWRFGTRFM SLIKEAHWEG LTGRITFNKT NGLRTDFDLD VISLKEEGLE KIGTWDPASG LNMTESQKGK PANITDSLSN RSLIVTTILE EPYVLFKKSD KPLYGNDRFE GYCIDLLREL STILGFTYEI RLVEDGKYGA QDDANGQWNG MVRELIDHKA DLAVAPLAIT YVREKVIDFS KPFMTLGISI LYRKPNGTNP GVFSFLNPLS P
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分子量
87 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GRIK2, also known as Glutamate Receptor Ionotropic, Kainate 2, is a subtype of kainate receptor that plays a critical role in synaptic transmission and plasticity in the central nervous system. It is involved in various neurological processes, including learning and memory, and has been implicated in several neurodegenerative disorders and psychiatric conditions. The functional characterization of GRIK2 and its associated signaling pathways is essential for understanding the molecular mechanisms underlying these conditions. Recombinant GRIK2 protein is a valuable tool for studying the receptor's structure-function relationships, investigating ligand binding, and elucidating its role in synaptic dynamics. Through the generation of recombinant GRIK2, researchers can perform biophysical analyses, explore pharmacological properties, and develop potential therapeutic interventions targeting GRIK2-related pathways. Given the receptor's significance in neurotransmission and its potential as a drug target, detailed studies involving its recombinant form are crucial for advancing our knowledge of excitatory neurotransmission and for developing strategies to modulate GRIK2 activities in various neurological disorders.
