Analytical Data
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基因名
LZTS1
- Application
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别名
Lzts1; Fez1Leucine zipper putative tumor suppressor 1; F37/Esophageal cancer-related gene-coding leucine-zipper motif; Fez1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P60853
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表达区间
2-599aa
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氨基酸序列
GSVSSLISGHSFHSKHCRASQYKLRKSSHLKKLNRYSDGLLRFGFSQDSGRGKSSSKMGKSEDFFYIKVSQKARGSHRPDYTALSSGDIGGQTGVDFDPATPPKLMPFSNQLEMSSDKGAVRPTAFKPVLPRSGAILHSSPESTSHQLHPMPPDKPKEQELKPGLCSGALSDSGRNSMSSLPTHSTTSSYQLDPLVTPVGPTSRFGGSAHNITQGIILQDSNMMSLKALSFSDGGSKLAHPGKADKGASCVRSPLSTDECTIQELEQKLLQRETALQKLQRSFDEKEFASGQTFEERPRRTRDELECLEPKSKLKPPSQKSQRTQQVLQLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTNFAPALEETQWEVCQKSGEISLLKQQLKESQLEVNTKASEILSLKAQLKDTRGKLDGMELKTQDLESALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELMELRAQAALHPAPLGPPGVGLTFSEDIPALQRELDRLRAELKEERQGHDQMSSGFQHERLVWKEEKEKVIQYQRQLQQSYLAMYQRNQRLEKALQQLARGDGPGEPFEIDLEGADIPYEDIIATEI
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分子量
74.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LZTS1, a member of the leucine zipper tumor suppressor family, has garnered significant attention in cancer research due to its potential role in tumorigenesis. Initially identified as a gene frequently downregulated in various cancers, including breast, lung, and colorectal cancers, LZTS1 is thought to function as a critical regulator of cell proliferation and apoptosis. Its localization to the cytoplasm and interactions with multiple signaling pathways, such as the p53 and AKT pathways, suggest that LZTS1 may influence tumor growth and survival. Moreover, studies have indicated that LZTS1 can modulate the cell cycle and impact chromosomal stability, further implicating it in oncogenic processes. The examination of LZTS1 as a recombinant protein allows researchers to explore its functional properties, elucidate its mechanisms of action, and assess its potential as a therapeutic target. Understanding LZTS1's role at the molecular level could offer insights into its tumor suppressive functions and its applicability in targeted cancer therapies. As a result, the study of LZTS1 is not only pivotal for elucidating the underlying mechanisms of cancer development but also holds promise for the development of novel diagnostic and therapeutic strategies.
