Analytical Data
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基因名
IgG2a
- Application
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别名
IgG2a；TBET；TBLYM；T-box transcription factor TBX21
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UL17
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表达区间
1-535aa
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氨基酸序列
MGIVEPGCGD MLTGTEPMPG SDEGRAPGAD PQHRYFYPEP GAQDADERRG GGSLGSPYPG GALVPAPPSR FLGAYAYPPR PQAAGFPGAG ESFPPPADAE GYQPGEGYAA PDPRAGLYPG PREDYALPAG LEVSGKLRVA LNNHLLWSKF NQHQTEMIIT KQGRRMFPFL SFTVAGLEPT SHYRMFVDVV LVDQHHWRYQ SGKWVQCGKA EGSMPGNRLY VHPDSPNTGA HWMRQEVSFG KLKLTNNKGA SNNVTQMIVL QSLHKYQPRL HIVEVNDGEP EAACNASNTH IFTFQETQFI AVTAYQNAEI TQLKIDNNPF AKGFRENFES MYTSVDTSIP SPPGPNCQFL GGDHYSPLLP NQYPVPSRFY PDLPGQAKDV VPQAYWLGAP RDHSYEAEFR AVSMKPAFLP SAPGPTMSYY RGQEVLAPGA GWPVAPQYPP KMGPASWFRP MRTLPMEPGP GGSEGRGPED QGPPLVWTEI APIRPESSDS GLGEGDSKRR RVSPYPSSGD SSSPAGAPSP FDKEAEGQFY NYFPN
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分子量
58.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
IgG2a, a subtype of immunoglobulin G (IgG), plays a crucial role in the immune response, particularly in the context of murine models where it has been linked to Th1-driven immune responses. The study of IgG2a recombinant proteins has gained prominence in fields such as vaccine development, autoimmune disease research, and therapeutic antibody design. Understanding the structural and functional characteristics of IgG2a can enhance the design of more effective vaccines and therapeutic agents that target specific pathogens or disease mechanisms. These recombinant proteins can be engineered to improve their efficacy, stability, and specificity, allowing for more precise targeting of antigens and better modulation of immune responses. Researchers are particularly interested in the unique properties of IgG2a, such as its ability to activate complement pathways and engage Fc receptors on immune cells, which may provide insights into designing next-generation immunotherapies. Additionally, IgG2a has been identified as a biomarker of certain immune responses, making its study relevant for diagnostic applications. The advances in recombinant DNA technology and protein expression systems have facilitated the production of high-quality IgG2a proteins, paving the way for comprehensive studies that elucidate their roles in health and disease. Overall, the ongoing research on IgG2a recombinant proteins holds promise for innovations in immunological therapies and enhanced understanding of immune system dynamics.
