Analytical Data
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Gene name
TEAD2
- Application
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Alternative Names
TEAD2；TEF4；Transcriptional enhancer factor TEF-4
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q15562
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Expression Region
217-447aa
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AA Sequence
AWQARGLGTARLQLVEFSAFVEPPDAVDSYQRHLFVHISQHCPSPGAPPLESVDVRQIYDKFPEKKGGLRELYDRGPPHAFFLVKFWADLNWGPSGEEAGAGGSISSGGFYGVSSQYESLEHMTLTCSSKVCSFGKQVVEKVETERAQLEDGRFVYRLLRSPMCEYLVNFLHKLRQLPERYMMNSVLENFTILQVVTNRDTQELLLCTAYVFEVSTSERGAQHHIYRLVRD
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Molecular Weight
33.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TEAD2, a member of the TEAD family of transcription factors, plays a crucial role in regulating gene expression linked to development, cell proliferation, and tissue homeostasis. This protein interacts with the Yes-associated protein (YAP) and the transcriptional coactivator PDCD5, influencing various biological processes such as cell growth, differentiation, and apoptosis. The dysregulation of TEAD2 has been implicated in several cancers, making it a significant target for therapeutic intervention. Given its importance in the Hippo signaling pathway, which controls organ size and tumorigenesis, researchers are increasingly focused on the structural and functional characterization of TEAD2. The recombinant expression of TEAD2 allows for detailed studies of its interactions and mechanisms within cellular contexts. By producing TEAD2 in a recombinant system, scientists can examine its binding affinities, post-translational modifications, and potential therapeutic effects in cancer models. This has opened new avenues for targeted therapies aimed at modulating TEAD2 activity to restore normal cellular functions or inhibit tumor growth. As ongoing research elucidates the molecular underpinnings of TEAD2's roles, better understanding could lead to innovative strategies for cancer treatment and potentially other diseases linked to cellular dysregulation.
