Analytical Data
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基因名
TEAD2
- Application
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别名
TEAD2；TEF4；Transcriptional enhancer factor TEF-4
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q15562
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表达区间
217-447aa
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氨基酸序列
AWQARGLGTARLQLVEFSAFVEPPDAVDSYQRHLFVHISQHCPSPGAPPLESVDVRQIYDKFPEKKGGLRELYDRGPPHAFFLVKFWADLNWGPSGEEAGAGGSISSGGFYGVSSQYESLEHMTLTCSSKVCSFGKQVVEKVETERAQLEDGRFVYRLLRSPMCEYLVNFLHKLRQLPERYMMNSVLENFTILQVVTNRDTQELLLCTAYVFEVSTSERGAQHHIYRLVRD
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分子量
33.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TEAD2, a member of the TEAD family of transcription factors, plays a crucial role in regulating gene expression linked to development, cell proliferation, and tissue homeostasis. This protein interacts with the Yes-associated protein (YAP) and the transcriptional coactivator PDCD5, influencing various biological processes such as cell growth, differentiation, and apoptosis. The dysregulation of TEAD2 has been implicated in several cancers, making it a significant target for therapeutic intervention. Given its importance in the Hippo signaling pathway, which controls organ size and tumorigenesis, researchers are increasingly focused on the structural and functional characterization of TEAD2. The recombinant expression of TEAD2 allows for detailed studies of its interactions and mechanisms within cellular contexts. By producing TEAD2 in a recombinant system, scientists can examine its binding affinities, post-translational modifications, and potential therapeutic effects in cancer models. This has opened new avenues for targeted therapies aimed at modulating TEAD2 activity to restore normal cellular functions or inhibit tumor growth. As ongoing research elucidates the molecular underpinnings of TEAD2's roles, better understanding could lead to innovative strategies for cancer treatment and potentially other diseases linked to cellular dysregulation.
