Analytical Data
-
Gene name
NNMT
- Application
-
Alternative Names
NNMT;Nicotinamide N-methyltransferase
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
P40261
-
Expression Region
1-264aa
-
AA Sequence
MESGFTSKDTYLSHFNPRDYLEKYYKFGSRHSAESQILKHLLKNLFKIFC LDGVKGDLLIDIGSGPTIYQLLSACESFKEIVVTDYSDQNLQELEKWLKK EPEAFDWSPVVTYVCDLEGNRVKGPEKEEKLRQAVKQVLKCDVTQSQPLG AVPLPPADCVLSTLCLDAACPDLPTYCRALRNLGSLLKPGGFLVIMDALK SSYYMIGEQKFSSLPLGREAVEAAVKEAGYTIEWFEVISQSYSSTMANNE GLFSLVARKLSRPL
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
NNMT (nicotinamide N-methyltransferase) is an important enzyme involved in the metabolism of nicotinamide, a form of vitamin B3. It plays a crucial role in regulating cellular energy and has gained interest for its potential implications in various pathological conditions, including cancer, obesity, and metabolic disorders. Research has shown that NNMT is overexpressed in several cancer types, leading to its recognition as a potential biomarker and therapeutic target. Additionally, NNMT's involvement in the methylation process suggests it could influence the epigenetic landscape of cells, further linking it to the development of diseases. Recent studies have focused on the recombinant expression of NNMT protein to better understand its biochemical properties, interactions, and role in cellular metabolism. Through the production of recombinant NNMT, researchers aim to explore the enzyme's structure-function relationship, investigate its regulatory mechanisms, and develop inhibitors that could serve as novel therapeutic agents. This research not only enhances our understanding of NNMT's biological functions but also opens avenues for innovative treatments for metabolic and oncological diseases by targeting this enzyme's activity.
