Analytical Data
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基因名
NHP2
- Application
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别名
NHP2;NOLA2;H/ACA ribonucleoProtein complex subunit 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NX24
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表达区间
1-153aa
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氨基酸序列
MGSSHHHHHHSSGLVPRGSHMTKIKADPDGPEAQAEACSGERTYQELLVN QNPIAQPLASRRLTRKLYKCIKKAVKQKQIRRGVKEVQKFVNKGEKGIMV LAGDTLPIEVYCHLPVMCEDRNLPYVYIPSKTDLGAAAGSKRPTCVIMVK PHEEYQEAYDECLEEVQSLPLPL
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分子量
19 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NHP2, or Nuclear Histone Protein 2, is a critical component involved in various cellular processes, particularly in the assembly and maintenance of the ribonucleoprotein complexes essential for RNA biogenesis and processing. Research into NHP2 has garnered attention due to its essential role in the biogenesis of the telomerase complex, which maintains telomere integrity and function in eukaryotic cells. Dysfunctional telomeres are implicated in aging and various diseases, including cancer. The study of NHP2 recombinant proteins has become increasingly relevant as scientists seek to understand its structural and functional properties. By producing NHP2 in a recombinant form, researchers can investigate its interactions with other telomeric proteins and RNA components, providing insights into the molecular mechanisms governing telomere maintenance and RNA metabolism. Additionally, characterizing the structural features of NHP2 through techniques such as X-ray crystallography and nuclear magnetic resonance (NMR) can aid in identifying potential therapeutic targets for diseases associated with telomere dysfunction. Overall, the exploration of NHP2 and its recombinant protein forms not only enhances our understanding of fundamental biological processes but also opens avenues for innovative approaches in cancer therapy and regenerative medicine.
