Analytical Data
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Gene name
NDE1
- Application
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Alternative Names
NDE1;NUDE;Nuclear distribution Protein nudE homolog 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NXR1
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Expression Region
1-335aa
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AA Sequence
MEDSGKTFSS EEEEANYWKD LAMTYKQRAE NTQEELREFQ EGSREYEAEL ETQLQQIETR NRDLLSENNR LRMELETIKE KFEVQHSEGY RQISALEDDL AQTKAIKDQL QKYIRELEQA NDDLERAKRA TIMSLEDFEQ RLNQAIERNA FLESELDEKE NLLESVQRLK DEARDLRQEL AVQQKQEKPR TPMPSSVEAE RTDTAVQATG SVPSTPIAHR GPSSSLNTPG SFRRGLDDST GGTPLTPAAR ISALNIVGDL LRKVGALESK LASCRNLVYD QSPNRTGGPA SGRSSKNRDG GERRPSSTSV PLGDKGLDTS CRWLSKSTTR SSSSC
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Molecular Weight
63 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NDE1 (Nuclear Distribution Gene E Homolog 1) is a crucial protein involved in the regulation of neuronal development and the maintenance of normal cellular functions. Its role in neurogenesis and neuronal migration has garnered considerable attention in recent years, particularly due to its implications in neurodevelopmental disorders and neuropsychiatric diseases. Research has shown that NDE1 interacts with various cytoskeletal components, influencing cell division and positioning within the developing brain. Mutations or dysregulation of NDE1 expression have been implicated in conditions such as schizophrenia and autism spectrum disorders, emphasizing the need for thorough exploration of this protein. Recombinant NDE1 protein production allows for detailed studies of its structure, function, and interactions at a molecular level, facilitating the understanding of its role in neuronal processes. This research is vital for uncovering potential therapeutic targets, as understanding how NDE1 influences cellular dynamics could lead to novel interventions for diseases linked to its dysfunction. Thus, the exploration of NDE1 as a recombinant protein is not only essential for basic neurobiological research but also holds promise for advancing therapeutic strategies in neurodevelopmental and psychiatric disorders.
