Analytical Data
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基因名
Nrg
- Application
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别名
Nrg；Pro-neuregulin-4. membrane-bound isoform
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P20241
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表达区间
610-814aa
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氨基酸序列
IVQDVPNAPKLTGITCQADKAEIHWEQQGDNRSPILHYTIQFNTSFTPASWDAAYEKVPNTDSSFVVQMSPWANYTFRVIAFNKIGASPPSAHSDSCTTQPDVPFKNPDNVVGQGTEPNNLVISWTPMPEIEHNAPNFHYYVSWKRDIPAAAWENNNIFDWRQNNIVIADQPTFVKYLIKVVAINDRGESNVAAEEVVGYSGEDR
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分子量
28.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The research into Nrg (neuregulin) recombinant proteins has gained significant traction within the fields of neurobiology and cancer research due to its crucial role in cellular signaling processes. Neuregulins are a family of growth factors that interact with the ErbB receptor tyrosine kinase family and are vital for various physiological functions, including neural development, cardiogenesis, and the modulation of synaptic activity. Aberrant Nrg signaling has been implicated in several pathological conditions, such as schizophrenia, breast cancer, and heart failure. The production of recombinant Nrg proteins allows researchers to investigate their specific functions, therapeutic potentials, and signaling mechanisms in various cellular contexts. By utilizing methods such as genetic engineering and recombinant DNA technology, scientists are able to produce these proteins in sufficient quantities for detailed studies. This exploration not only enhances our understanding of neuregulin's role in development and disease but also aids in the identification of potential therapeutic targets and strategies. Overall, the study of recombinant Nrg proteins stands at the intersection of fundamental biology and clinical applications, paving the way for innovative approaches to treat conditions associated with Nrg dysregulation.
