Analytical Data
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Gene name
NBL1
- Application
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Alternative Names
NBL1;DAN;DAND1;Neuroblastoma suppressor of tumorigenicity 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P41271
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Expression Region
2-180aa
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AA Sequence
MMLRVLVGAV LPAMLLAAPP PINKLALFPD KSAWCEAKNI TQIVGHSGCE AKSIQNRACL GQCFSYSVPN TFPQSTESLV HCDSCMPAQS MWEIVTLECP GHEEVPRVDK LVEKILHCSC QACGKEPSHE GLSVYVQGED GPGSQPGTHP HPHPHPHPGG QTPEPEDPPG APHTEEEGAE D
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Molecular Weight
19 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NBL1, or Neuroblastoma suppressor of tumorigenicity 1, is a member of the transforming growth factor-beta (TGF-β) superfamily and plays a crucial role in various biological processes, including cell differentiation, proliferation, and apoptosis. Its involvement in neuroblastoma, a common pediatric cancer, has drawn significant research interest, as studies have suggested that NBL1 may act as a tumor suppressor, impacting tumor growth and metastasis. The characterization of NBL1 and its signaling pathways can provide insights into its function and implications in cancer biology. Research efforts have focused on the production of recombinant NBL1 proteins to study their structure and biological activities in vitro and in vivo. These recombinant proteins can help delineate the mechanisms by which NBL1 influences cellular behavior, including its interactions with receptors and other signaling molecules. Furthermore, understanding the role of NBL1 in neuroblastoma may pave the way for novel therapeutic strategies, as manipulating its activity could offer new avenues for treatment. Given the complexity of cancer development and the need for effective therapies, the exploration of NBL1 as a potential target highlights the importance of basic research in the context of translational medicine.
