Analytical Data
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Gene name
MAT1A
- Application
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Alternative Names
MAT1A;AMS1;MATA1;S-adenosylmethionine synthase isoform type-1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q00266
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Expression Region
1-395aa
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AA Sequence
MNGPVDGLCDHSLSEGVFMFTSESVGEGHPDKICDQISDAVLDAHLKQDPNAKVACETVCKTGMVLLCGEITSMAMVDYQRVVRDTIKHIGYDDSAKGFDFKTCNVLVALEQQSPDIAQCVHLDRNEEDVGAGDQGLMFGYATDETEECMPLTIILAHKLNARMADLRRSGLLPWLRPDSKTQVTVQYMQDNGAVIPVRIHTIVISVQHNEDITLEEMRRALKEQVIRAVVPAKYLDEDTVYHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKAGLCRRVLVQVSYAIGVAEPLSISIFTYGTSQKTERELLDVVHKNFDLRPGVIVRDLDLKKPIYQKTACYGHFGRSEFPWEVPRKLVF
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Molecular Weight
47.3kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
MAT1A (Methionine Adenosyltransferase 1A) is an essential enzyme involved in the synthesis of S-adenosylmethionine (SAM), a critical methyl donor in various biological processes, including methylation of DNA, proteins, and lipids. Dysregulation of MAT1A has been implicated in liver disease and other metabolic disorders. Increased understanding of MAT1A function and regulation can provide insights into its role in liver physiology and pathology. Recent studies have highlighted the significance of MAT1A in hepatocyte function and its potential as a therapeutic target for liver-related conditions. Researchers are investigating the structure and function of MAT1A through the production of recombinant proteins, enabling detailed studies of its enzymatic activity and interactions with other cellular components. Such insights could pave the way for novel therapeutic strategies to mitigate liver diseases and improve metabolic health. The emphasis on MAT1A research reflects the growing recognition of the importance of methylation processes in cellular homeostasis and disease mechanisms.
