Analytical Data
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Gene name
JMJD8
- Application
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Alternative Names
JMJD8；C16orf20；JmjC domain-containing Protein 8
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96S16
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Expression Region
24-264aa
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AA Sequence
EGDGGWRPGGPGAVAEEERCTVERRADLTYAEFVQQYAFVRPVILQGLTDNSRFRALCSRDRLLASFGDRVVRLSTANTYSYHKVDLPFQEYVEQLLHPQDPTSLGNDTLYFFGDNNFTEWASLFRHYSPPPFGLLGTAPAYSFGIAGAGSGVPFHWHGPGYSEVIYGRKRWFLYPPEKTPEFHPNKTTLAWLRDTYPALPPSARPLECTIRAGEVLYFPDRWWHATLNLDTSVFISTFLG
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Molecular Weight
34.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
JMJD8 is a member of the Jumonji C (JmjC) domain-containing protein family, which is known for its role as an enzyme with demethylase activity, particularly targeting specific lysine residues on histones. This protein has garnered attention due to its implications in various biological processes, including gene regulation, cellular differentiation, and pathways linked to cancer and other diseases. Previous studies have indicated that JMJD8 may play a pivotal role in modulating chromatin structure and gene expression, thereby influencing cellular responses to various environmental cues. Despite this, the functional mechanisms of JMJD8 remain underexplored, particularly regarding its substrate specificity and structural properties. Research into the recombinant protein of JMJD8 aims to elucidate these mechanisms by allowing detailed biochemical and biophysical analyses, which could provide insights into its role in epigenetic regulation. Understanding JMJD8's structure-function relationship is crucial for developing potential therapeutic strategies targeting related pathologies, making it an important subject of study in molecular biology and medical research.
