Analytical Data
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基因名
MAT2B
- Application
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别名
MAT2B;TGR;Methionine adenosyltransferase 2 subunit beta
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NZL9
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表达区间
2-334aa
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氨基酸序列
VGREKELSIHFVPGSCRLVEEEVNIPNRRVLVTGATGLLGRAVHKEFQQN NWHAVGCGFRRARPKFEQVNLLDSNAVHHIIHDFQPHVIVHCAAERRPDV VENQPDAASQLNVDASGNLAKEAAAVGAFLIYISSDYVFDGTNPPYREED IPAPLNLYGKTKLDGEKAVLENNLGAAVLRIPILYGEVEKLEESAVTVMF DKVQFSNKSANMDHWQQRFPTHVKDVATVCRQLAEKRMLDPSIKGTFHWS GNEQMTKYEMACAIADAFNLPSSHLRPITDSPVLGAQRPRNAQLDCSKLE TLGIGQRTPFRIGIKESLWPFLIDKRWRQTVFH
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分子量
39 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MAT2B, or Methionine Adenosyltransferase 2B, is a critical enzyme involved in the biosynthesis of S-adenosylmethionine (SAM), a pivotal methyl donor in various biological processes, including methylation of DNA, RNA, and proteins. The enzyme has garnered considerable research interest due to its role in cellular metabolism, regulation of gene expression, and involvement in neurodegenerative diseases, such as Alzheimer's and Parkinson's. Alterations in MAT2B expression have been linked to cognitive decline and neuroinflammation, highlighting its potential as a therapeutic target. Furthermore, MAT2B has been found to possess protective effects against oxidative stress and is thought to play a role in maintaining neuronal health. The investigation of MAT2B as a recombinant protein allows researchers to explore its enzymatic properties, interaction with other biomolecules, and its potential implications in disease treatment and prevention. By further elucidating the structure-function relationships of MAT2B, researchers aim to harness its biological activities for drug development and therapeutic strategies, paving the way for innovations in treating conditions associated with SAM metabolism dysregulation. As a result, MAT2B recombinant protein studies are vital for understanding its biological functions and exploring its therapeutic possibilities in both neuroprotection and metabolic regulation.
