Analytical Data
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Gene name
KRT13
- Application
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Alternative Names
KRT13；Keratin. type I cytoskeletal 13
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P13646
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Expression Region
1-458aa
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AA Sequence
MSLRLQSSSASYGGGFGGGSCQLGGGRGVSTCSTRFVSGGSAGGYGGGVSCGFGGGAGSGFGGGYGGGLGGGYGGGLGGGFGGGFAGGFVDFGACDGGLLTGNEKITMQNLNDRLASYLEKVRALEEANADLEVKIRDWHLKQSPASPERDYSPYYKTIEELRDKILTATIENNRVILEIDNARLAADDFRLKYENELALRQSVEADINGLRRVLDELTLSKTDLEMQIESLNEELAYMKKNHEEEMKEFSNQVVGQVNVEMDATPGIDLTRVLAEMREQYEAMAERNRRDAEEWFHTKSAELNKEVSTNTAMIQTSKTEITELRRTLQGLEIELQSQLSMKAGLENTVAETECRYALQLQQIQGLISSIEAQLSELRSEMECQNQEYKMLLDIKTRLEQEIATYRSLLEGQDAKMIGFPSSAGSVSPRSTSVTTTSSASVTTTSNASGRRTSDVRRP
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Molecular Weight
57.0 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KRT13, or Keratin 13, is a type of intermediate filament protein primarily expressed in the epithelial tissues of the human body, particularly in mucosal surfaces such as the oral cavity and esophagus. As a component of the cytoskeleton, KRT13 plays a crucial role in maintaining cellular integrity and tissue architecture, and it is vital for the protection against mechanical stress and chemical insults. Alterations in KRT13 expression have been associated with various pathological conditions, including keratinization disorders and certain types of cancer, underscoring its potential as a biomarker for disease progression and a target for therapeutic intervention. Recent advances in recombinant protein technology have enabled the production of purified KRT13, facilitating the study of its structure-function relationships and interactions with other cellular components. Characterizing KRT13 at the molecular level can provide insights into its role in maintaining epithelial homeostasis and its involvement in tissue regeneration and repair processes. Additionally, understanding how KRT13 interacts with other keratins and proteins within the cell can enhance our comprehension of its contribution to various diseases. Thus, research on recombinant KRT13 not only extends our knowledge of keratin biology but also opens avenues for developing novel diagnostic and therapeutic strategies.
