Analytical Data
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基因名
UGT1A7
- Application
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别名
UGT1A7；GNT1；UGT1；UDP-glucuronosyltransferase 1A7
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9HAW7
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表达区间
26-530aa
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氨基酸序列
GKLLVVPMDGSHWFTMQSVVEKLILRGHEVVVVMPEVSWQLGRSLNCTVKTYSTSYTLEDQDREFMVFADARWTAPLRSAFSLLTSSSNGIFDLFFSNCRSLFNDRKLVEYLKESCFDAVFLDPFDACGLIVAKYFSLPSVVFARGIFCHYLEEGAQCPAPLSYVPRLLLGFSDAMTFKERVWNHIMHLEEHLFCPYFFKNVLEIASEILQTPVTAYDLYSHTSIWLLRTDFVLEYPKPVMPNMIFIGGINCHQGKPVPMEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH
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分子量
60.0 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The UGT1A7 gene encodes a member of the UDP-glucuronosyltransferase (UGT) family of enzymes, which are crucial for the detoxification and elimination of various endogenous and exogenous compounds through the process of glucuronidation. This metabolic pathway plays a vital role in drug metabolism, pharmacokinetics, and the clearance of potentially harmful substances from the body. Research on UGT1A7 is particularly significant due to its involvement in the metabolism of several therapeutic agents and carcinogens, making it important for cancer research and drug development. Variants in the UGT1A7 gene can lead to differences in enzyme activity, impacting individual responses to drugs and susceptibility to toxic effects. The recombinant expression of UGT1A7 proteins in suitable systems allows for the detailed study of their biochemical properties, substrate specificity, and interactions with drugs. Understanding these characteristics is essential for predicting drug efficacy and safety, as well as for developing personalized medicine approaches. As a result, the investigation of UGT1A7 and its substrate interactions has garnered considerable interest across various fields, including pharmacology, toxicology, and cancer therapy, making it a pivotal enzyme in understanding individual metabolic responses and therapeutic interventions.
