Analytical Data
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基因名
PARL
- Application
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别名
PARL；PSARL；Presenilin-associated rhomboid-like Protein. mitochondrial
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9H300
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表达区间
53-379aa
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氨基酸序列
FRKAPRKVEPRRSDPGTSGEAYKRSALIPPVEETVFYPSPYPIRSLIKPLFFTVGFTGCAFGSAAIWQYESLKSRVQSYFDGIKADWLDSIRPQKEGDFRKEINKWWNNLSDGQRTVTGIIAANVLVFCLWRVPSLQRTMIRYFTSNPASKVLCSPMLLSTFSHFSLFHMAANMYVLWSFSSSIVNILGQEQFMAVYLSAGVISNFVSYVGKVATGRYGPSLGASGAIMTVLAAVCTKIPEGRLAIIFLPMFTFTAGNALKAIIAMDTAGMILGWKFFDHAAHLGGALFGIWYVTYGHELIWKNREPLVKIWHEIRTNGPKKGGGSK
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分子量
37.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PARL (Presenilin-Associated Rhomboid-Like protein) is a mitochondria-associated protease that plays a crucial role in maintaining mitochondrial function and regulating cellular homeostasis. Research into PARL has gained momentum due to its involvement in key biological processes such as apoptosis, mitochondrial dynamics, and protein quality control. Its dysregulation has been implicated in various neurodegenerative diseases, including Alzheimer's disease, where it interacts with presenilin proteins, affecting amyloid-β production. Recent studies have focused on understanding the structural and functional characteristics of PARL, as well as its substrate specificity, to elucidate its role in pathophysiological contexts. Investigations into PARL's enzymatic activity and the regulatory mechanisms governing its function may provide new insights into potential therapeutic strategies for mitochondrial dysfunction and neurodegeneration. Given the increasing recognition of the mitochondria's role in disease processes, PARL's research is positioned at the intersection of cell biology and neurobiology, promising to uncover novel pathways for intervention in age-related and degenerative disorders.
