Analytical Data
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基因名
LAMTOR2
- Application
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别名
LAMTOR2;MAPBPIP;ROBLD3;Ragulator complex Protein LAMTOR2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Y2Q5
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表达区间
1-125aa
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氨基酸序列
MGSSHHHHHHSSGLVPRGSHMGSHMLRPKALTQVLSQANTGGVQSTLLLN NEGSLLAYSGYGDTDARVTAAIASNIWAAYDRNGNQAFNEDNLKFILMDC MEGRVAITRVANLLLCMYAKETVGFGMLKAKAQALVQYLEEPLTQVAAS
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分子量
16 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LAMTOR2 (Late Endosomal/Lysosomal Adaptation Protein 2) plays a critical role in the mTOR (mechanistic target of rapamycin) signaling pathway, which is central to cellular growth, proliferation, and metabolism. This protein is part of the larger LAMTOR (Late Endosomal/MAPK-Organizing Protein) complex, involved in the regulation of lysosomal function and nutrient sensing. Research indicates that LAMTOR2 interacts with various signaling molecules, influencing cellular responses to growth factors and nutrients. Mutations or dysregulation of LAMTOR2 have been implicated in several diseases, including cancer and metabolic disorders, highlighting its importance in maintaining cellular homeostasis. The recombinant production of LAMTOR2 has become essential for understanding its structure-function relationships and for investigating its role in mTOR signaling. By generating LAMTOR2 as a recombinant protein, researchers can explore its biochemical properties, interactions with other proteins, and its contribution to lysosomal dynamics. This line of research not only enhances our understanding of fundamental cellular processes but also opens avenues for therapeutic interventions targeting mTOR-related diseases.
