Analytical Data
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基因名
CD45
- Application
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别名
CD45；CD45；Receptor-type tyrosine-Protein phosphatase C
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P08575
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表达区间
26-577aa
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氨基酸序列
QSPTPSPTGLTTAKMPSVPLSSDPLPTHTTAFSPASTFERENDFSETTTSLSPDNTSTQVSPDSLDNASAFNTTGVSSVQTPHLPTHADSQTPSAGTDTQTFSGSAANAKLNPTPGSNAISDVPGERSTASTFPTDPVSPLTTTLSLAHHSSAALPARTSNTTITANTSDAYLNASETTTLSPSGSAVISTTTIATTPSKPTCDEKYANITVDYLYNKETKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNASVSISHNSCTAPDKTLILDVPPGVEKFQLHDCTQVEKADTTICLKWKNIETFTCDTQNITYRFQCGNMIFDNKEIKLENLEPEHEYKCDSEILYNNHKFTNASKIIKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVEAGNTLVRNESHKNCDFRVKDLQYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSK
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分子量
76.8kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CD45, also known as leukocyte common antigen, is a critical transmembrane glycoprotein expressed on the surface of all hematopoietic cells, playing a vital role in regulating immune responses. It functions primarily as a receptor-type protein tyrosine phosphatase, modulating the activation of T and B lymphocytes through its role in dephosphorylating key signaling molecules. Given its essential involvement in immune cell activation and differentiation, CD45 has attracted significant attention in immunology research. Alterations in CD45 expression or function are linked to various diseases, including autoimmune disorders, cancers, and infections. The study of CD45 recombinant proteins has emerged as a valuable approach to understand its precise mechanisms of action, investigate its potential as a therapeutic target, and develop engineered proteins for therapeutic applications. These recombinant proteins enable researchers to dissect the roles of specific CD45 isoforms and their signaling pathways, paving the way for novel strategies in immunotherapy and vaccine development. Additionally, characterizing CD45 in different disease contexts can reveal insights into immune dysregulation and help identify biomarkers for disease progression and treatment response. As a result, the ongoing exploration of CD45 through recombinant techniques holds promise for enhancing our understanding of immune regulation and improving therapeutic interventions in various immunological conditions.
