Analytical Data
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Gene name
KISS1
- Application
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Alternative Names
KISS1;Metastasis-suppressor KiSS-1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q15726
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Expression Region
20-138aa
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AA Sequence
E PLEKVASVGN SRPTGQQLES LGLLAPGEQS LPCTERKPAA TARLSRRGTS LSPPPESSGS PQQPGLSAPH SRQIPAPQGA VLVQREKDLP NYNWNSFGLR FGKREAAPGN HGRSAGRG
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
KISS1, a gene encoding the kisspeptin peptide, plays a crucial role in the regulation of the reproductive endocrine system. Discovered in the late 1990s, KISS1 and its product, kisspeptin, were initially identified for their involvement in metastatic cancer progression. However, subsequent studies revealed their fundamental role in initiating puberty and regulating gonadotropin-releasing hormone (GnRH) secretion, thereby influencing reproductive functions. The KISS1 protein is secreted and acts through the GPR54 receptor, modulating hypothalamic signaling pathways. Abnormalities in KISS1 expression have been linked to reproductive disorders, including hypogonadotropic hypogonadism and precocious puberty. Research on KISS1 recombinant protein has intensified as scientists explore its potential therapeutic applications, including fertility treatments and cancer therapy. By understanding the structure and function of the KISS1 protein, researchers aim to develop novel strategies for manipulating reproductive processes and addressing associated pathologies. Current studies focus on elucidating the signaling mechanisms and interactions of kisspeptin, promoting a deeper comprehension of its physiological roles and potential clinical implications.
