Analytical Data
-
基因名
KIR2DS4
- Application
-
别名
KIR2DS4;CD158I;KKA3;NKAT8;Killer cell immunoglobulin-like receptor 2DS4
-
种属
Human
-
表达系统
E. coli
-
标签
His tag N-Terminus
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
P43632
-
表达区间
22-304aa
-
氨基酸序列
QEGVHRKPSFLALPGHLVKSEETVILQCWSDVMFEHFLLHREGKFNNTLHLIGEHHDGVSKANFSIGPMMPVLAGTYRCYGSVPHSPYQLSAPSDPLDMVIIGLYEKPSLSAQPGPTVQAGENVTLSCSSRSSYDMYHLSREGEAHERRLPAVRSINGTFQADFPLGPATHGGTYRCFGSFRDAPYEWSNSSDPLLVSVTGNPSNSWPSPTEPSSKTGNPRHLHVLIGTSVVKIPFTILLFFLLHRWCSDKKNAAVMDQEPAGNRTVNSEDSDEQDHQEVSYA
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
KIR2DS4 is a member of the Killer Immunoglobulin-like Receptor (KIR) family, which plays a crucial role in the regulation of natural killer (NK) cell activity and immune responses. Unlike its inhibitory counterparts, KIR2DS4 is an activating receptor that can trigger NK cell cytotoxicity against target cells, including virus-infected and tumor cells. The study of KIR2DS4 is particularly relevant in the context of its potential implications in transplantation, cancer immunotherapy, and infectious diseases. Research has shown that variations in the KIR2DS4 gene can influence immune responses, and its expression patterns can differ among populations, highlighting its relevance in understanding genetic predispositions to diseases. Recombinant protein studies of KIR2DS4 aim to elucidate its structure-function relationship, signaling mechanisms, and interactions with ligands. Such studies can aid in the development of therapeutics that harness NK cell activity, providing insights into how to enhance immune responses in various clinical settings, including malignancies and viral infections. Understanding KIR2DS4 could ultimately contribute to the advancement of personalized medicine approaches that tailor immunotherapy based on individual KIR profiles.
