Analytical Data
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Gene name
KIR2DS4
- Application
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Alternative Names
KIR2DS4;CD158I;KKA3;NKAT8;Killer cell immunoglobulin-like receptor 2DS4
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P43632
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Expression Region
22-304aa
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AA Sequence
QEGVHRKPSFLALPGHLVKSEETVILQCWSDVMFEHFLLHREGKFNNTLHLIGEHHDGVSKANFSIGPMMPVLAGTYRCYGSVPHSPYQLSAPSDPLDMVIIGLYEKPSLSAQPGPTVQAGENVTLSCSSRSSYDMYHLSREGEAHERRLPAVRSINGTFQADFPLGPATHGGTYRCFGSFRDAPYEWSNSSDPLLVSVTGNPSNSWPSPTEPSSKTGNPRHLHVLIGTSVVKIPFTILLFFLLHRWCSDKKNAAVMDQEPAGNRTVNSEDSDEQDHQEVSYA
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
KIR2DS4 is a member of the Killer Immunoglobulin-like Receptor (KIR) family, which plays a crucial role in the regulation of natural killer (NK) cell activity and immune responses. Unlike its inhibitory counterparts, KIR2DS4 is an activating receptor that can trigger NK cell cytotoxicity against target cells, including virus-infected and tumor cells. The study of KIR2DS4 is particularly relevant in the context of its potential implications in transplantation, cancer immunotherapy, and infectious diseases. Research has shown that variations in the KIR2DS4 gene can influence immune responses, and its expression patterns can differ among populations, highlighting its relevance in understanding genetic predispositions to diseases. Recombinant protein studies of KIR2DS4 aim to elucidate its structure-function relationship, signaling mechanisms, and interactions with ligands. Such studies can aid in the development of therapeutics that harness NK cell activity, providing insights into how to enhance immune responses in various clinical settings, including malignancies and viral infections. Understanding KIR2DS4 could ultimately contribute to the advancement of personalized medicine approaches that tailor immunotherapy based on individual KIR profiles.
