Cat: PA1000-1656

Recombinant Human ING2 Protein,His

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Analytical Data

  • Gene name

    ING2

  • Application

    SPRMSTBLIITCELISACELL ASSAYDRUG SCREENING

  • Alternative Names

    ING2;ING1L;Inhibitor of growth Protein 2

  • Species

    Human

  • Source

    E. coli

  • Tag

    His tag N-Terminus

  • Purity

    Greater than 90% as determined by SDS-PAGE.

  • Uniprot

    Q9H160

  • Expression Region

    1-280aa

  • AA Sequence

    MGSSHHHHHH SSGLVPRGSH MGSMLGQQQQ QLYSSAALLT GERSRLLTCY VQDYLECVES LPHDMQRNVS VLRELDNKYQ ETLKEIDDVY EKYKKEDDLN QKKRLQQLLQ RALINSQELG DEKIQIVTQM LELVENRARQ MELHSQCFQD PAESERASDK AKMDSSQPER SSRRPRRQRT SESRDLCHMA NGIEDCDDQP PKEKKSKSAK KKKRSKAKQE REASPVEFAI DPNEPTYCLC NQVSYGEMIG CDNEQCPIEW FHFSCVSLTY KPKGKWYCPK CRGDNEKTMD KSTEKTKKDR RSR

  • Molecular Weight

    35 kDa

  • Endotoxin

    < 1.0 EU per μg protein as determined by the LAL method.

  • Form

    Freeze-dried powder

  • Buffer formulation

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • Reconstitution

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • Customization

    Site-directed mutagenesis Custom tag design Custom buffer formulation Custom full-length protein production

  • Stability Test

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • Storage & Shelf Life

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • Shipping

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

Quality inspection process

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Protein Description

ING2 (Inhibitor of Growth 2) is a member of the ING family of proteins, known for their roles in regulating cell growth and apoptosis. As a candidate tumor suppressor gene, ING2 has garnered interest in cancer research, particularly regarding its involvement in pathways that maintain genomic stability and influence apoptosis. Research indicates that ING2 is frequently downregulated or lost in various cancer types, suggesting that its deficiency may contribute to tumorigenesis. The protein is known to interact with various chromatin-remodeling complexes, influencing gene expression and cellular responses to stress. Studies have also shown that ING2 can inhibit the activity of oncogenic transcription factors, thereby reinforcing its role in restraining uncontrolled cell proliferation. Given its significant function in cancer biology, ING2 has become a target of interest for therapeutic approaches aimed at restoring its expression and function in malignancies. Understanding the molecular mechanisms underlying ING2's activity could provide valuable insights into novel cancer treatment strategies, emphasizing the importance of ongoing research into this intriguing protein.

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