Analytical Data
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Gene name
GKN2
- Application
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Alternative Names
GKN2；BLOT；GDDR；TFIZ1；Gastrokine-2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q86XP6
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Expression Region
21-184aa
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AA Sequence
YEVFNIISPS NNGGNVQETV TIDNEKNTAI INIHAGSCSS TTIFDYKHGY IASRVLSRRA CFILKMDHQN IPPLNNLQWY IYEKQALDNM FSSKYTWVKY NPLESLIKDV DWFLLGSPIE KLCKHIPLYK GEVVENTHNV GAGGCAKAGL LGILGISICA DIHV
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Molecular Weight
20.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GKN2 (Gastric Kinesin 2) is a member of the GKN family of proteins, which are notably associated with gastric mucosal defense and repair processes. The interest in GKN2 has surged due to its potential role in various gastrointestinal diseases, including gastric cancer, chronic gastritis, and peptic ulcers. Studies have shown that GKN2 exhibits anti-inflammatory properties and is crucial for maintaining mucosal integrity in response to injury or infection. Moreover, altered expression levels of GKN2 have been linked to the disease progression in gastric conditions, prompting research into its molecular mechanisms and potential as a therapeutic target. Recent investigations involve the production of recombinant GKN2 proteins to study their structure, function, and interactions with other biomolecules. By utilizing advanced cloning and expression techniques, researchers aim to produce sufficient quantities of this protein for functional assays, structural characterization, and potential drug development. Understanding the role of GKN2 in gastric pathophysiology could pave the way for novel therapeutic strategies and biomarkers for early diagnosis in gastric diseases. Thus, the study of recombinant GKN2 is a promising area of research that bridges basic science and clinical applications, offering insights into gastric health and disease management.
