Analytical Data
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Gene name
IRX1
- Application
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Alternative Names
IRX1; IRXA1; Iroquois-class homeodomain protein IRX-1; Homeodomain protein IRXA1; Iroquois homeobox protein 1
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P78414
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Expression Region
1-480aa
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AA Sequence
MSFPQLGYPQYLSAAGPGAYGGERPGVLAAAAAAAAAASSGRPGAAELGGGAGAAAVTSVLGMYAAAGPYAGAPNYSAFLPYAADLSLFSQMGSQYELKDNPGVHPATFAAHTAPAYYPYGQFQYGDPGRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKVTWGARSKDQEDGALFGSDTEGDPEKAEDDEEIDLESIDIDKIDEHDGDQSNEDDEDKAEAPHAPAAPSALARDQGSPLAAADVLKPQDSPLGLAKEAPEPGSTRLLSPGAAAGGLQGAPHGKPKIWSLAETATSPDGAPKASPPPPAGHPGAHGPSAGAPLQHPAFLPSHGLYTCHIGKFSNWTNSAFLAQGSLLNMRSFLGVGAPHAAPHGPHLPAPPPPQPPVAIAPGALNGDKASVRSSPTLPERDLVPRPDSPAQQLKSPFQPVRDNSLAPQEGTPRILAALPSA
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Molecular Weight
52.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
IRX1 (Iroquois homeobox 1) is a crucial transcription factor involved in various developmental processes, particularly in embryogenesis and organogenesis. Located on chromosome 5, IRX1 is part of the Iroquois homeobox gene family, which plays significant roles in regulating gene expression patterns during early development. Research indicates that IRX1 is essential for the proper formation of the nervous system and limb structures, with its expression being tightly regulated during various stages of development. Abnormal IRX1 activity has been implicated in several developmental disorders and diseases, including congenital malformations and certain cancers. The study of IRX1 recombinant proteins has become increasingly relevant as scientists seek to understand its intricate role in gene regulation and development. By utilizing recombinant technology, researchers can produce IRX1 proteins in vitro, enabling detailed functional analyses that clarify how IRX1 interacts with other molecular partners and influences downstream targets. This research not only sheds light on the fundamental mechanisms of development but also holds potential for therapeutic applications, as manipulating IRX1 activity could offer insights into novel treatments for developmental disorders and malignancies. Overall, the investigation into IRX1 recombinant proteins is pivotal for elucidating the biological functions of this transcription factor and for advancing our understanding of developmental biology and pathology.
