Analytical Data
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Gene name
INPP4B
- Application
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Alternative Names
Inositol polyphosphate 4 phosphatase. type II; 4-bisphosphate 4-phosphatase; Inositol polyphosphate 4 phosphatase type II 105kDa; Inositol polyphosphate 4-phosphatase type II; INP4B_HUMAN; Inpp4b; MGC132014; Type II inositol 3.4 bisphosphate 4 phosphatase; Type II inositol-3
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O15327
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Expression Region
1-53aa
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AA Sequence
MEIKEEGASEEGQHFLPTAQANDPGDCQFTSIQKTPNEPQLEFILDLNQELRD
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Molecular Weight
31.57 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
INPP4B, or Inositol Polyphosphate-4-Phosphatase B, is an enzyme that plays a critical role in cellular signaling pathways, particularly those involving phosphoinositides, which are essential for a variety of cellular processes such as metabolism, cell proliferation, and survival. The dysregulation of INPP4B has been implicated in various diseases, including cancer, where its expression levels can influence tumor progression and response to therapeutic interventions. Recent studies have highlighted the potential of INPP4B as a tumor suppressor, particularly in certain types of cancers, suggesting that it may act as a negative regulator of the PI3K/Akt signaling pathway. Research into recombinant INPP4B protein has gained traction as scientists seek to elucidate its structure-function relationship and the specific mechanisms by which it exerts its effects in the cell. The production of a recombinant form of this protein allows for detailed biochemical studies and opens avenues for potential therapeutic applications, including the development of novel inhibitors or modulators that can target this pathway in disease contexts. Furthermore, understanding INPP4B's role in cellular signaling can provide insights into broader questions regarding cell biology and the interplay between various signaling networks, highlighting its significance in both basic research and clinical settings.
