Analytical Data
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Gene name
OPRM1
- Application
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Alternative Names
OPRM1；MOR1；Mu-type opioid receptor
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P35372
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Expression Region
1-400aa
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AA Sequence
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRT DLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTK MKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDY YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAI GLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLII TVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHI YVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFR EFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
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Molecular Weight
45 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
OPRM1 (opioid receptor mu 1) is a critical gene that encodes the mu-opioid receptor, which plays a vital role in the regulation of pain, reward, and addictive behaviors. Understanding the function and mechanism of OPRM1 is crucial for the development of effective analgesics and treatments for opioid addiction, given the rising global opioid crisis. Research has shown that variations in the OPRM1 gene can influence individual responses to opioid analgesics and susceptibility to addiction. The recombinant protein of OPRM1 serves as a valuable tool in biochemical studies, enabling researchers to investigate the receptor's structure, signaling pathways, and interactions with various ligands. Through expressing and purifying OPRM1 recombinant proteins, scientists can analyze the effects of different drugs, elucidate the receptor's pharmacodynamics, and explore the impact of genetic polymorphisms on function. This research is particularly relevant for designing targeted therapies that minimize side effects and enhance treatment efficacy for patients suffering from chronic pain and opioid dependence. Furthermore, studying OPRM1's role in cell signaling may contribute to the development of novel strategies for managing opioid-related disorders, emphasizing the essential nature of this receptor in both fundamental and applied biomedical research.
