Analytical Data
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Gene name
C1rl
- Application
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Alternative Names
C1rl；C1RL1；C1RLP；CLSPA；Complement C1r subcomponent-like Protein
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Species
Mouse
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q3UZ09
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Expression Region
44-482aa
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AA Sequence
SVLLAQQSPQQLTSPGYPEPYLKGQESHTDIEAPEGFAVRLTFQDFDLEPSPDCEGDSVTISTGGTDATRLCGRQGSPLGNPPGHREFVSSGRSLRLTFQAHSSSKSKITHLHKGFLALYQAVAVNQPNGDTEAVTTPGAPKIQNHCQDPYYKADQTGTLSCPSSWKWKDRQDGGEVPECVPVCGRPVVPLAENPNTFGSSRAKLGNFPWQAFTSIYGRGGGALLGDRWILTAAHTIYPKDSIYLRRNQNVEVFLGHTDIDELLKLGNHPVRRVVVHPDYRQHESHNFNGDIALLELEQRVPLGPNLLPVCLPDNETLYHSGLWGYVSGFGVEMGWLTTKLKYSKLPVAPREACEAWLHQRQRTEVFSDNMFCVGEEMQVNSVCQGDSGSVYVVWDDLALRWVATGIVSWGIGCGKGYGFYTKVLSYMDWIKRVIEGKD
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Molecular Weight
50 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
C1rl, a member of the complement system, plays a pivotal role in immune responses and has garnered significant attention for its involvement in various pathological conditions. This protein, specifically an integral part of the regulatory mechanisms of the complement cascade, is essential for the modulation of inflammation and the prevention of tissue damage during immune reactions. Studies have shown that dysregulation of C1rl can lead to autoimmune diseases and contribute to the pathogenesis of conditions such as systemic lupus erythematosus and rheumatoid arthritis. Researchers have been increasingly focused on the structural and functional characterization of C1rl to better understand its interactions with other components of the immune system. Recombinant protein studies have emerged as a powerful tool to investigate the functional properties of C1rl, employing techniques such as protein engineering and expression in heterologous systems. These studies aim to elucidate the mechanisms underlying C1rl activity, paving the way for potential therapeutic interventions targeting complement dysregulation. As the interest in personalized medicine continues to grow, the exploration of C1rl and its associated pathways offers promising avenues for the development of novel treatments for complement-related diseases, emphasizing the importance of this protein in both basic and applied biomedical research.
