Analytical Data
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Gene name
PTF1a
- Application
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Alternative Names
PTF1a；BHLHA29；PTF1P48；Pancreas transcription factor 1 subunit alpha
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q7RTS3
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Expression Region
1-328aa
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AA Sequence
MDAVLLEHFP GGLDAFPSSY FDEDDFFTDQ SSRDPLEDGD ELLADEQAEV EFLSHQLHEY CYRDGACLLL QPAPPAAPLA LAPPSSGGLG EPDDGGGGGY CCETGAPPGG FPYSPGSPPS CLAYPCAGAA VLSPGARLRG LSGAAAAAAR RRRRVRSEAE LQQLRQAANV RERRRMQSIN DAFEGLRSHI PTLPYEKRLS KVDTLRLAIG YINFLSELVQ ADLPLRGGGA GGCGGPGGGG RLGGDSPGSQ AQKVIICHRG TRSPSPSDPD YGLPPLAGHS LSWTDEKQLK EQNIIRTAKV WTPEDPRKLN SKSSFNNIEN EPPFEFVS
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Molecular Weight
34.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PTF1a, or Pancreas-Associated Transcription Factor 1a, is a crucial transcription factor involved in the development and function of the pancreas and its associated tissues. It belongs to the basic helix-loop-helix (bHLH) family of proteins and plays a pivotal role in initiating and maintaining the pancreatic progenitor state during embryonic development. Researchers have identified that PTF1a is essential for the differentiation of pancreatic exocrine cells and the regulation of insulin-producing β-cells, making it a vital component in understanding pancreatic development and function. Given its significant role in endocrine and exocrine pancreatic tissues, PTF1a has gained attention in the context of studying pancreatic disorders, including diabetes and pancreatic cancer. The generation of recombinant PTF1a proteins has enabled scientists to investigate its molecular interactions, regulatory mechanisms, and potential therapeutic applications. By utilizing techniques such as recombinant DNA technology and protein expression systems, researchers aim to further elucidate the pathways regulated by PTF1a, thereby providing insights into its function and potential as a target for therapeutic interventions in pancreatic diseases. Understanding the biology and regulation of PTF1a is thus critical for advancing both basic research in developmental biology and potential clinical applications in treating pancreatic-related disorders.
